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Edg8/S1P5: An Oligodendroglial Receptor with Dual Function on Process Retraction and Cell Survival
Endothelial differentiation gene (Edg) proteins are G-protein-coupled receptors activated by lysophospholipid mediators: sphingosine-1-phosphate (S1P) or lysophosphatidic acid. We show that in theExpand
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Induction of myelination in the central nervous system by electrical activity.
The oligodendrocyte is the myelin-forming cell in the central nervous system. Despite the close interaction between axons and oligodendrocytes, there is little evidence that neurons influenceExpand
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Ciliary Neurotrophic Factor (CNTF) Enhances Myelin Formation: A Novel Role for CNTF and CNTF-Related Molecules
In multiple sclerosis, myelin repair is generally insufficient despite the relative survival of oligodendrocytes within the plaques and the recruitment of oligodendrocyte precursors. PromotingExpand
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  • Open Access
Clinical Relevance of Brain Volume Measures in Multiple Sclerosis
Multiple sclerosis (MS) is a chronic disease with an inflammatory and neurodegenerative pathology. Axonal loss and neurodegeneration occurs early in the disease course and may lead to irreversibleExpand
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  • Open Access
Negative regulation of central nervous system myelination by polysialylated-neural cell adhesion molecule.
Many factors have been shown to promote myelination, but few have been shown to be inhibitory. Here, we show that polysialylated-neural cell adhesion molecule (PSA-NCAM) can negatively regulateExpand
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  • Open Access
Imaging of CNS myelin by positron-emission tomography.
Promoting myelin repair is one of the most promising therapeutic avenues in the field of myelin disorders. In future clinical trials, evaluation of remyelination will require a reliable andExpand
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  • Open Access
Clinical and neuropathologic variation in neuronal intermediate filament inclusion disease
Background: Recently described neuronal intermediate filament inclusion disease (NIFID) shows considerable clinical heterogeneity. Objective: To assess the spectrum of the clinical andExpand
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  • Open Access
Imaging central nervous system myelin by positron emission tomography in multiple sclerosis using [methyl‐11C]‐2‐(4′‐methylaminophenyl)‐ 6‐hydroxybenzothiazole
Imaging of myelin tracts in vivo would greatly improve the monitoring of demyelinating diseases such as multiple sclerosis (MS). To date, no imaging technique specifically targets demyelination andExpand
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Brain networks disconnection in early multiple sclerosis cognitive deficits: An anatomofunctional study
Severe cognitive impairment involving multiple cognitive domains can occur early during the course of multiple sclerosis (MS). We investigated resting state functional connectivity changes inExpand
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Oligodendroglial Expression of Edg-2 Receptor: Developmental Analysis and Pharmacological Responses to Lysophosphatidic Acid
Edg-2 is a member of the G-protein-coupled seven-transmembrane receptor family recently identified in oligodendrocytes. Here we show that both in vitro and in vivo, Edg-2 transcripts are not detectedExpand
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