B. Sproule

Publications100
h-index28
Citations3,332
Highly Influential Citations119
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Sedative hypnotics in older people with insomnia: meta-analysis of risks and benefits
Abstract Objectives To quantify and compare potential benefits (subjective reports of sleep variables) and risks (adverse events and morning-after psychomotor impairment) of short term treatment with… Expand
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Buprenorphine: clinical pharmacokinetics in the treatment of opioid dependence.
Buprenorphine is a semi-synthetic opioid derived from thebaine, a naturally occurring alkaloid of the opium poppy, Papaver somniferum. The pharmacology of buprenorphine is unique in that it is a… Expand
  • 208
  • 8
Lithium in Bipolar Disorder
The evidence is reviewed for effective serum lithium concentrations for the acute and prophylactic treatment of mania and depression in patients with bipolar disorder. The efficacy of lithium in the… Expand
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Prescription opioid abuse in patients presenting for methadone maintenance treatment.
To characterize prescription opioid dependent patients in a methadone maintenance treatment (MMT) program, a detailed retrospective chart review of new admissions (1997-1999, n=178, mean… Expand
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Assessing anhedonia in depression: Potentials and pitfalls
The resurgence of interest in anhedonia within major depression has been fuelled by clinical trials demonstrating its utility in predicting antidepressant response as well as recent… Expand
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Differential Pharmacokinetics of Lithium in Elderly Patients
The pharmacotherapeutic use of lithium in the elderly as acute and maintenance therapy in bipolar disorder and augmentation therapy for major depression is well documented. Differences in the… Expand
  • 128
  • 6
Toward the development of a Mood Disorders Insight Scale: modification of Birchwood's Psychosis Insight Scale.
BACKGROUND Insight has been defined as: (1) recognition of symptomatology, (2) the ability to attribute symptoms to a mental health disorder, and (3) complying with treatment. Insight is related to… Expand
  • 45
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Inhibition of human cytochrome P450 2D6 (CYP2D6) by methadone.
1. In microsomes prepared from three human livers, methadone competitively inhibited the O-demethylation of dextromethorphan, a marker substrate for CYP2D6. The apparent Ki value of methadone ranged… Expand
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Community pharmacists' attitudes toward and professional interactions with users of psychiatric medication.
Consumers of psychiatric medications or services may be stigmatized by health care providers. The authors surveyed community pharmacists (N=283) in the greater Toronto area to determine their… Expand
  • 140
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Changing patterns in opioid addiction: characterizing users of oxycodone and other opioids.
OBJECTIVE To evaluate the clinical observation that the number of individuals seeking opioid detoxification from oxycodone was increasing at the Centre for Addiction and Mental Health (CAMH) in… Expand
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  • 5
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