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Aminoglycoside binding to the HIV-1 RNA dimerization initiation site: thermodynamics and effect on the kissing-loop to duplex conversion
Owing to a striking, and most likely fortuitous, structural and sequence similarity with the bacterial 16 S ribosomal A site, the RNA kissing-loop complex formed by the HIV-1 genomic RNA dimerizationExpand
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Synthesis, calcium mobilizing, and physicochemical properties of D-chiro-inositol 1,3,4,6-tetrakisphosphate, a novel and potent ligand at the D-myo-inositol 1,4,5-trisphosphate receptor.
The synthesis of a novel and potent ligand at the D-myo-inositol 1,4, 5-trisphosphate receptor (InsP3R) is described. D-chiro-Inositol 1,3, 4,6-tetrakisphosphate (7) and L-chiro-inositol 1,3,4,Expand
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A general approach toward the synthesis of C-nucleoside pyrazolo[1,5-a]-1,3,5-triazines and their 3',5'-bisphosphate C-nucleotide analogues as the first reported in vivo stable P2Y(1)-receptor
In our effort to identify potent purinergic P2Y(1) receptor antagonists as potent platelet aggregation inhibitors with enhanced metabolic stability, we developed an efficient route for theExpand
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myo-Inositol 1,4,5-triphosphate and related compounds′ protonation sequence: potentiometric and 31P NMR studies
The protonation sequence of myo-inositol 1,4,5-triphosphate [Ins(1,4,5)P3], of its dehydroxylated analogue, Cyhx(1,2,4) P3, of two diphosphorylated inositol phosphates, Ins(1,4)P2 and Ins(4,5)P2 andExpand
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Inframolecular studies of the protonation of adenophostin A: comparison with 1-D-myo-inositol 1,4,5-trisphosphate.
Adenophostin A is a glyconucleotide natural product with the highest known potency for the D-myo-inositol 1,4,5-trisphosphate receptor. Using synthetic adenophostin A we have investigated theExpand
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Influence of substituents upon the basicity, spectral characteristics, and lipophilicity of a series of 3-aminopyridazines
The protonation and partition thermodynamics of a series of substituted 3-aminopyridazines have been studied. The lead compound, 4-methyl-3-(2-morpholinoethylamino)-6-phenylpyridazine, minaprine, isExpand
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Synthesis and binding properties of myo-inositol 4,5,6-tris(phosphate) an analogue of myo-inositol 1,4,5-tris(phosphate). Correlation with the ionization state of the molecules
Abstract Myo -inositol 4,5,6-tris(phosphate) is synthetized. The binding activity for this analogue with the CNS Ins(1,4,5)P 3 receptors is explained by taking into account steric modification and,Expand
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Determination of the pK(a) of the four Zn2+-coordinating residues of the distal finger motif of the HIV-1 nucleocapsid protein: consequences on the binding of Zn2+.
The nucleocapsid protein NCp7 of human immunodeficiency virus type 1 is characterized by two highly conserved CCHC motifs that bind Zn2+ strongly. To elucidate the striking pH-dependence of theExpand
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Inframolecular Protonation Process of myo-Inositol 1,4,5-Tris(phosphate) and Related Compounds: Dynamics of the Intramolecular Interactions and Evidence of C−H···O Hydrogen Bonding
The inframolecular protonation process of myo-inositol 1,4,5-tris(phosphate) (1, Ins(1,4,5)P3) and the closely related analogues myo-inositol 1,4,6-tris(phosphate) (2, Ins(1,4,6)P3), andExpand
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Complete Resolution of the Microscopic Protonation Equilibria of D-myo-Inositol 1,2,6-Tris(phosphate) and Related Compounds by 31P NMR and Potentiometry
31 P NMR and potentiometric titration experiments allowed the complete microconstant system to be resolved for D-myo-inositol 1,2,6-tris(phosphate) [Ins(1,2,6)P 3 ] and DL-myo-inositolExpand
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