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PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
An analytical strategy is introduced, Gene Set Enrichment Analysis, designed to detect modest but coordinate changes in the expression of groups of functionally related genes, which identifies a set of genes involved in oxidative phosphorylation whose expression is coordinately decreased in human diabetic muscle. Expand
A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis
- P. Puigserver, Z. Wu, C. Park, R. Graves, M. Wright, B. Spiegelman
- Medicine, Biology
- 20 March 1998
Results indicate that PGC-1 plays a key role in linking nuclear receptors to the transcriptional program of adaptive thermogenesis. Expand
Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance.
A role for TNF-alpha in obesity and particularly in the insulin resistance and diabetes that often accompany obesity is indicated. Expand
Mechanisms Controlling Mitochondrial Biogenesis and Respiration through the Thermogenic Coactivator PGC-1
PGC-1, a cold-inducible coactivator of nuclear receptors, stimulates mitochondrial biogenesis and respiration in muscle cells through an induction of uncoupling protein 2 (UCP-2) and through regulation of the nuclear respiratory factors (NRFs). Expand
A PGC1-\(\alpha\)-dependent Myokine that Drives Brown-fat-like Development of White Fat and Thermogenesis
Exercise benefits a variety of organ systems in mammals, and some of the best-recognized effects of exercise on muscle are mediated by the transcriptional coactivator PGC1α Here we show that PGC1α… Expand
Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human
Beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone irisin, providing evidence that previously identified brown fat deposits in adult humans are composed of beige adipocytes. Expand
Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1.
It is shown that the Sir2 homologue, SIRT1 controls the gluconeogenic/glycolytic pathways in liver in response to fasting signals through the transcriptional coactivator PGC-1alpha, and this finding has strong implications for the basic pathways of energy homeostasis, diabetes and lifespan. Expand
Suppression of Reactive Oxygen Species and Neurodegeneration by the PGC-1 Transcriptional Coactivators
Increase in PGC-1alpha levels dramatically protects neural cells in culture from oxidative-stressor-mediated death, providing a potential target for the therapeutic manipulation of these important endogenous toxins. Expand
Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1
The results implicate PGC-1 as a key modulator of hepatic gluconeogenesis and as a central target of the insulin–cAMP axis in liver. Expand
AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha.
- Sibylle Jäger, C. Handschin, J. St-Pierre, B. Spiegelman
- Proceedings of the National Academy of Sciences…
The data indicate that AMPK phosphorylation of PGC-1alpha initiates many of the important gene regulatory functions of AMPK in skeletal muscle. Expand