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Cloning and Characterization of a Mammalian Lithium-sensitive Bisphosphate 3′-Nucleotidase Inhibited by Inositol 1,4-Bisphosphate*
- B. Spiegelberg, J. Xiong, J. J. Smith, R. Gu, J. York
- Medicine, Biology
- The Journal of Biological Chemistry
- 7 May 1999
Discovery of a structurally conserved metal-dependent lithium-inhibited phosphomonoesterase protein family has identified several potential cellular targets of lithium as used to treat manic… Expand
Gβγ Interferes with Ca2+-Dependent Binding of Synaptotagmin to the Soluble N-Ethylmaleimide-Sensitive Factor Attachment Protein Receptor (SNARE) Complex
- E. Yoon, Tatyana Gerachshenko, B. Spiegelberg, S. Alford, H. Hamm
- Medicine, Biology
- Molecular Pharmacology
- 1 November 2007
Presynaptic inhibitory G protein-coupled receptors (GPCRs) can decrease neurotransmission by inducing interaction of Gβγ with the soluble N-ethylmaleimide-sensitive factor attachment protein receptor… Expand
An expanded view of inositol signaling.
Roles of G-protein-coupled receptor signaling in cancer biology and gene transcription.
G-protein-coupled receptors (GPCRs) are ubiquitous mediators of signal transduction across mammalian cell membranes. Among other roles, GPCRs are known to regulate cellular motility, growth and… Expand
Interaction of Gβγ with RACK1 and other WD40 repeat proteins
Abstract Heterotrimeric G-proteins, composed of Gα and Gβγ subunits, transmit numerous and diverse extracellular stimuli via a large family of heptahelical cell-surface receptors to various… Expand
Interaction of Gbetagamma with RACK1 and other WD40 repeat proteins.
- S. Chen, B. Spiegelberg, Fang Lin, E. J. Dell, H. Hamm
- Journal of molecular and cellular cardiology
Heterotrimeric G-proteins, composed of Galpha and Gbetagamma subunits, transmit numerous and diverse extracellular stimuli via a large family of heptahelical cell-surface receptors to various… Expand
Scaffolding and Docking Proteins in the Heart Interaction of Gbc with RACK1 and other WD40 repeat proteins
Heterotrimeric G-proteins, composed of Ga and Gbc subunits, transmit numerous and diverse extracellular stimuli via a large family of heptahelical cell-surface receptors to various intracellular… Expand
Alteration of Lithium Pharmacology through Manipulation of Phosphoadenosine Phosphate Metabolism*
- B. Spiegelberg, J. dela Cruz, Tzuo-Hann Law, J. York
- Biology, Medicine
- Journal of Biological Chemistry
- 18 February 2005
Bisphosphate 3′-nucleotidase (BPNT1 in mammals and Met22/Hal2 in yeast) is one of five members of a family of signaling phosphatases united through a common tertiary structure and inhibition by… Expand
G betagamma binds histone deacetylase 5 (HDAC5) and inhibits its transcriptional co-repression activity.
In a yeast two-hybrid screen designed to identify novel effectors of the G betagamma subunit of heterotrimeric G proteins, we found that G betagamma binds to histone deacetylase 5 (HDAC5), an enzyme… Expand
Nuclear inositol signaling: a structural and functional approach.