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Cloning and Characterization of a Mammalian Lithium-sensitive Bisphosphate 3′-Nucleotidase Inhibited by Inositol 1,4-Bisphosphate*
Discovery of a structurally conserved metal-dependent lithium-inhibited phosphomonoesterase protein family has identified several potential cellular targets of lithium as used to treat manicExpand
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Gβγ Interferes with Ca2+-Dependent Binding of Synaptotagmin to the Soluble N-Ethylmaleimide-Sensitive Factor Attachment Protein Receptor (SNARE) Complex
Presynaptic inhibitory G protein-coupled receptors (GPCRs) can decrease neurotransmission by inducing interaction of Gβγ with the soluble N-ethylmaleimide-sensitive factor attachment protein receptorExpand
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An expanded view of inositol signaling.
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Roles of G-protein-coupled receptor signaling in cancer biology and gene transcription.
G-protein-coupled receptors (GPCRs) are ubiquitous mediators of signal transduction across mammalian cell membranes. Among other roles, GPCRs are known to regulate cellular motility, growth andExpand
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Interaction of Gβγ with RACK1 and other WD40 repeat proteins
Abstract Heterotrimeric G-proteins, composed of Gα and Gβγ subunits, transmit numerous and diverse extracellular stimuli via a large family of heptahelical cell-surface receptors to variousExpand
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Interaction of Gbetagamma with RACK1 and other WD40 repeat proteins.
Heterotrimeric G-proteins, composed of Galpha and Gbetagamma subunits, transmit numerous and diverse extracellular stimuli via a large family of heptahelical cell-surface receptors to variousExpand
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Scaffolding and Docking Proteins in the Heart Interaction of Gbc with RACK1 and other WD40 repeat proteins
Heterotrimeric G-proteins, composed of Ga and Gbc subunits, transmit numerous and diverse extracellular stimuli via a large family of heptahelical cell-surface receptors to various intracellularExpand
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Alteration of Lithium Pharmacology through Manipulation of Phosphoadenosine Phosphate Metabolism*
Bisphosphate 3′-nucleotidase (BPNT1 in mammals and Met22/Hal2 in yeast) is one of five members of a family of signaling phosphatases united through a common tertiary structure and inhibition byExpand
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G betagamma binds histone deacetylase 5 (HDAC5) and inhibits its transcriptional co-repression activity.
In a yeast two-hybrid screen designed to identify novel effectors of the G betagamma subunit of heterotrimeric G proteins, we found that G betagamma binds to histone deacetylase 5 (HDAC5), an enzymeExpand
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Nuclear inositol signaling: a structural and functional approach.
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