• Publications
  • Influence
Presynaptically Located CB1 Cannabinoid Receptors Regulate GABA Release from Axon Terminals of Specific Hippocampal Interneurons
To understand the functional significance and mechanisms of action in the CNS of endogenous and exogenous cannabinoids, it is crucial to identify the neural elements that serve as the structuralExpand
  • 1,043
  • 96
  • PDF
P2X7 receptors in the nervous system
P2X(7) receptors are ligand-gated ion channels, expressed as homo-oligomeric assemblies of individual subunits. They are widely distributed at immunocompetent cells of the central and peripheralExpand
  • 346
  • 24
  • PDF
Involvement of P2X7 receptors in the regulation of neurotransmitter release in the rat hippocampus
Although originally cloned from rat brain, the P2X7 receptor has only recently been localized in neurones, and functional responses mediated by these neuronal P2X7 receptors (P2X7R) are largelyExpand
  • 232
  • 22
  • PDF
P2X7 receptor: an emerging target in central nervous system diseases.
The ATP-sensitive homomeric P2X7 receptor (P2X7R) has received particular attention as a potential drug target because of its widespread involvement in inflammatory diseases as a key regulatoryExpand
  • 225
  • 18
Involvement of Cannabinoid Receptors in the Regulation of Neurotransmitter Release in the Rodent Striatum: A Combined Immunochemical and Pharmacological Analysis
Despite the profound effect of cannabinoids on motor function, and their therapeutic potential in Parkinson's and Huntington's diseases, the cellular and subcellular distributions of striatal CB1Expand
  • 219
  • 18
  • PDF
Neurochemical Changes in the Mouse Hippocampus Underlying the Antidepressant Effect of Genetic Deletion of P2X7 Receptors
Recent investigations have revealed that the genetic deletion of P2X7 receptors (P2rx7) results in an antidepressant phenotype in mice. However, the link between the deficiency of P2rx7 and changesExpand
  • 64
  • 11
  • PDF
GABAergic interneurons are the targets of cannabinoid actions in the human hippocampus
Cannabinoids have been shown to disrupt memory processes in mammals including humans. Although the CB1 neuronal cannabinoid receptor was identified several years ago, neuronal network mechanismsExpand
  • 242
  • 8
  • PDF
Low-density lipoprotein mimics blood plasma-derived exosomes and microvesicles during isolation and detection
Circulating extracellular vesicles have emerged as potential new biomarkers in a wide variety of diseases. Despite the increasing interest, their isolation and purification from body fluids remainsExpand
  • 202
  • 8
  • PDF
Cannabinoids inhibit the release of [3H]glutamate from rodent hippocampal synaptosomes via a novel CB1 receptor‐independent action
In this study we investigated the effect of cannabinoids on [3H]glutamate release from hippocampal synaptosomes of rat and CB1‐null mutant mouse. In the rat, cannabinoid receptor agonists, i.e.Expand
  • 73
  • 8
ATP released by LPS increases nitric oxideproduction in raw 264.7 macrophage cell line viaP2Z⧹P2X7 receptors
P2Z/P2X7 receptor is a particular type of purinoceptor, which is selectively expressed on the surface of immune cells in neuronal and non-neuronal tissues. Despite intensive research on itsExpand
  • 130
  • 7