Author pages are created from data sourced from our academic publisher partnerships and public sources.
- Publications
- Influence
In vitro hepatotoxicity of the cyanobacterial alkaloid cylindrospermopsin and related synthetic analogues.
- M. Runnegar, C. Xie, B. Snider, G. Wallace, S. Weinreb, J. Kuhlenkamp
- Chemistry, Medicine
- Toxicological sciences : an official journal of…
- 1 May 2002
Cylindrospermopsin (CY), a sulfate ester of a tricyclic guanidine substituted with a hydroxymethyluracil, is a cyanobacterial toxin of increasing environmental import as it frequently occurs in… Expand
Molecular profiling of Mycobacterium tuberculosis identifies tuberculosinyl nucleoside products of the virulence-associated enzyme Rv3378c
- Emilie Layre, H. J. Lee, +10 authors D. Moody
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 10 February 2014
Significance Whereas most mycobacteria do not cause disease, Mycobacterium tuberculosis kills more than one million people each year. To better understand why Mycobacterium tuberculosis is virulent… Expand
Synthesis of 2,3-dihydro-3-hydroxy-2-hydroxylalkylbenzofurans from epoxy aldehydes. One-step syntheses of brosimacutin G, vaginidiol, vaginol, smyrindiol, xanthoarnol, and Avicenol A. Biomimetic…
We have developed two practical one-step syntheses of 2,3-dihydro-3-hydroxy-2-hydroxyalkylbenzofurans from readily available optically pure alpha,beta-epoxy aldehydes. Electron-deficient resorcinols… Expand
Structure revision and syntheses of epohelmins A and B.
[structures: see text] Epohelmins A (24) and B (26) have been reassigned as pyrrolizidin-1-ols, rather than the proposed 9-oxa-4-azabicyclo[6.1.0]nonane structures 1 and 2, respectively. Syntheses of… Expand
Synthesis of the carbocyclic skeleton of abyssomicins C and D.
[reaction: see text] Intramolecular Diels-Alder substrate trienyl methylenebutenolide 5 was prepared in six steps by coupling 3-methoxy-4-methylenebutenolide (6) with trienone keto aldehyde 7.… Expand
An Improved Procedure for the Conversion of Alkenes and Glycals to 1,2-Diazides Using Mn(OAc)3·2H2O in Acetonitrile Containing Trifluoroacetic Acid
Abstract Alkenes and Glycals react with Mn(OAc3)·2H2O and NaN3 in 9:1 acetonitrile-trifluoroacetic acid to give 1,2-diazides in >80% yield. Allylic azides are formed by slow addition of NaN3 to a… Expand
Total Synthesis of (+/-)-Leporin A.
An efficient synthesis of (+/-)-leporin A (1) has been developed using a tandem Knoevenagel condensation-inverse electron demand intramolecular hetero Diels-Alder reaction to construct the key… Expand
Biomimetic synthesis of the bicyclic guanidine moieties of crambines A and B
The acyl portions of crambine A (six steps, 29% overall yield) and crambine B (six steps, 26% overall yield) have been efficiently and stereospecifically synthesized from methyl acetoacetate
Synthesis of (+)-sch 642305 by a biomimetic transannular Michael reaction.
[reaction: see text] The synthesis of (+)-Sch 642305 (1) has been completed in 17 steps in 1.6% overall yield. Transannular Michael reaction of 2b with NaH in THF provided cyclohexenone 23… Expand