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High-generation polycationic dendrimers are unusually effective at disrupting anionic vesicles: membrane bending model.
The membrane disruption properties of high generation (G4 to G7) poly(amidoamine) (PAMAM) dendrimers are evaluated and compared to linear poly(lysine). The G6 and G7 dendrimers are unusuallyExpand
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Detection of apoptotic cells using a synthetic fluorescent sensor for membrane surfaces that contain phosphatidylserine
Detection of apoptotic cells using a synthetic fluorescent sensor for membrane surfaces that contain phosphatidylserine
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Facilitated Transport of Small Carbohydrates through Plasticized Cellulose Triacetate Membranes. Evidence for Fixed-Site Jumping Transport Mechanism
Facilitated transport through liquid membranes has been investigated for more than 30 years as a potential separations technology. 1 Although liquid membranes have many promising attributes, thereExpand
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Anion recognition using dimetallic coordination complexes
This article describes advances made over the past 3 years in anion recognition using coordination complexes, with a specific focus on dimetallic architectures that utilize a bridging mechanism. TheExpand
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Squaraine rotaxanes: superior substitutes for Cy-5 in molecular probes for near-infrared fluorescence cell imaging.
Recent breakthroughs in fluorescence microscopy are producing notable improvements in imaging resolution.[ 1 ] These ongoing technical advances should have a major positive impact on the emergingExpand
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Biomarkers and molecular probes for cell death imaging and targeted therapeutics.
Cell death is a critically important biological process. Disruption of homeostasis, either by excessive or deficient cell death, is a hallmark of many pathological conditions. Recent researchExpand
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Chemical control of phospholipid distribution across bilayer membranes
Most biological membranes possess an asymmetric transbilayer distribution of phospholipids. Endogenous enzymes expend energy to maintain the arrangement by promoting the rate of phospholipidExpand
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Optical imaging of bacterial infection in living mice using a fluorescent near-infrared molecular probe.
An optical imaging probe was synthesized by attaching a near-infrared carbocyanine fluorophore to an affinity group containing two zinc(II) dipicolylamine (Zn-DPA) units. The probe has a strong andExpand
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Squaraine-derived rotaxanes: highly stable, fluorescent near-IR dyes.
Squaraines are fluorescent, near-IR dyes with promising photophysical properties for biomedical applications. A limitation with these dyes is their inherent reactivity with nucleophiles, which leadsExpand
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New reagents for phosphatidylserine recognition and detection of apoptosis.
The phospholipid bilayer surrounding animal cells is made up of four principle phospholipid components, phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylserine (PS), andExpand
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