B. Smith

Publications35
h-index21
Citations4,295
Highly Influential Citations164
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Molecular structure of the water channel through aquaporin CHIP. The hourglass model.
Aquaporin channel-forming integral protein (CHIP) is the first characterized water channel protein (genome symbol AQP1), but the molecular structure of the aqueous pathway through CHIP remains… Expand
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Aquaporin CHIP: the archetypal molecular water channel.
Despite longstanding interest by nephrologists and physiologists, the molecular identities of membrane water channels remained elusive until recognition of CHIP, a 28-kDa channel-forming integral… Expand
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Reconstitution of functional water channels in liposomes containing purified red cell CHIP28 protein.
Water rapidly crosses the plasma membranes of red blood cells (RBCs) and renal tubules through highly specialized channels. CHIP28 is an abundant integral membrane protein in RBCs and renal tubules,… Expand
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Identification, purification, and partial characterization of a novel Mr 28,000 integral membrane protein from erythrocytes and renal tubules.
A novel Mr 28,000 integral membrane protein ("28kDa") was identified in human erythrocytes and found entirely associated with the Triton X-100 insoluble membrane skeletons. Antibodies to 28kDa… Expand
  • 568
  • 15
Intracellular receptors for activated protein kinase C. Identification of a binding site for the enzyme.
Protein kinase C (PKC) isozymes comprise a family of cytosolic enzymes that translocate to different intracellular sites on activation. We have recently characterized at least two intracellular… Expand
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Ultrastructure, pharmacologic inhibition, and transport selectivity of aquaporin channel-forming integral protein in proteoliposomes.
Reconstitution of highly purified aquaporin CHIP (channel-forming integral protein) into proteoliposomes was previously shown to confer high osmotic water permeability (Pf) to the membranes [Zeidel… Expand
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The human AQP4 gene: definition of the locus encoding two water channel polypeptides in brain.
  • M. Lu, M. Lee, +6 authors P. M. Deen
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1 October 1996
The aquaporin family of membrane water transport proteins are expressed in diverse tissues, and in brain the predominant water channel protein is AQP4. Here we report the isolation and… Expand
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Functional Analysis of Aquaporin-1 Deficient Red Cells
The aquaporin-1 (AQP1) water transport protein contains a polymorphism corresponding to the Colton red blood cell antigens. To define the fraction of membrane water permeability mediated by AQP1, red… Expand
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Developmental gene expression and tissue distribution of the CHIP28 water-channel protein.
The CHIP28 water channel is a major component of red cell and renal tubule membranes; however, its ontogeny and tissue distribution remain undefined. Three patterns of expression were identified when… Expand
  • 150
  • 5
Functional analyses of aquaporin water channel proteins.
Abstract This article summarizes methods for the chemical synthesis and biophysical characterization of gramicidins with varying sequences and labels. The family of gramicidin channels has developed… Expand
  • 42
  • 5