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Mechanism of Human SIRT1 Activation by Resveratrol*
The NAD+-dependent protein deacetylase family, Sir2 (or sirtuins), is important for many cellular processes including gene silencing, regulation of p53, fatty acid metabolism, cell cycle regulation,Expand
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Query by humming: musical information retrieval in an audio database
The emergence of audio and video data types in databases will require new information retrieval methods adapted to the specific characteristics and needs of these data types. An effective and naturalExpand
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Lorcaserin, a Novel Selective Human 5-Hydroxytryptamine2C Agonist: in Vitro and in Vivo Pharmacological Characterization
5-Hydroxytryptamine (5-HT)2C receptor agonists hold promise for the treatment of obesity. In this study, we describe the in vitro and in vivo characteristics of lorcaserinExpand
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Chemical mechanisms of histone lysine and arginine modifications.
Histone lysine and arginine residues are subject to a wide array of post-translational modifications including methylation, citrullination, acetylation, ubiquitination, and sumoylation. TheExpand
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Passive capture and structuring of lectures
Despite recent advances in authoring systems and tools, creating multimedia presentations remains a labor-intensive process. This paper describes a system for automatically constructing structuredExpand
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Characterizing user access to videos on the World Wide Web
Despite evidence of rising popularity of video on the web (or VOW), little is known about how users access video. However, such a characterization can greatly benefit the design of multimedia systemsExpand
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Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction.
Emerging evidence suggests that protein acetylation is a broad-ranging regulatory mechanism. Here we utilize acetyl-peptide arrays and metabolomic analyses to identify substrates of mitochondrialExpand
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A Continuous Media Player
The design and implementation of a continuous media player for Unix workstations is described. The player can play synchronized digital video and audio read from a file server. The systemExpand
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Performance of a software MPEG video decoder
The design and implementation of a software decoder for MPEG video bitstreams is described. The software has been ported to numerous platforms including PC''s, workstations, and mainframe computers.Expand
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Nitric oxide synthase domain interfaces regulate electron transfer and calmodulin activation
Significance The biological role of nitric oxide (NO) in mammalian physiology is now well established as a signaling molecule in the cardiovascular and nervous systems and as a chemical component inExpand
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