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Activated and unactivated platelet adhesion to monocytes and neutrophils.
Platelet-heterotypic cell adhesion is a dynamic process reflecting the activation status of the platelet and differential binding abilities of leukocytes, and the kinetics of platelet adhesion to monocytes and PMN indicate that monocyteAdhesion is favored over neutrophil adhesion.
Autoimmune oophoritis as a mechanism of follicular dysfunction in women with 46,XX spontaneous premature ovarian failure.
Isolated thrombocytopenia after allogeneic bone marrow transplantation: existence of transient and chronic thrombocytopenic syndromes.
- L. First, B. Smith, J. Lipton, D. Nathan, R. Parkman, J. Rappeport
- Medicine, BiologyBlood
- 1 February 1985
It is concluded that isolated thrombocytopenia represents a significant complication of bone marrow transplantation, particularly in patients receiving hematopoietic ablative preparatory regimens, and that it is the chronic, not the transient, throm bocytopenic syndrome that is associated with an adverse patient prognosis.
Human monoclonal thyroid stimulating autoantibody
Dynamics of leukocyte-platelet adhesion in whole blood.
Monocytes have a competitive advantage over PMN in binding activated platelets, particularly when less potent platelet agonists are used; and platelet aggregate formation initially competes unactivated platelets off leukocytes; subsequent aggregate dissociation allows the now activated platelet to readhere to monocytes and PMN through GMP-140.
AN IMPROVED RADIORECEPTOR ASSAY FOR TSH RECEPTOR ANTIBODIES
Analysis of serum samples from patients with Graves' disease, Hashimoto's disease, multinodular goitre, rheumatoid arthritis and normal donors suggested that the assay could detect TSH receptor antibodies in about 80% of patients (treated and untreated) with Graves’ disease.
Cardiopulmonary bypass induces leukocyte-platelet adhesion.
It is concluded that CPB, through increased platelet GMP-140 expression, causes formation of monocyte-platelet, and to a lesser extent, PMN-platelets conjugates.
Blockade of C5a and C5b-9 generation inhibits leukocyte and platelet activation during extracorporeal circulation.
This model suggests that the terminal components C5a and C5b-9, but not C3a, directly contribute to platelet and neutrophil activation during extracorporeal circulation, and identifies the C5 component as a site for therapeutic intervention in cardiopulmonary bypass.
Platelet-leukocyte activation and modulation of adhesion receptors in pediatric patients with congenital heart disease undergoing cardiopulmonary bypass.
Lymphocyte adhesion-dependent calcium signaling in human endothelial cells
- S. Pfau, D. Leitenberg, H. Rinder, B. Smith, R. Pardi, J. Bender
- BiologyThe Journal of cell biology
- 1 March 1995
The results implicate the IP/Ca2+ second messenger pathway in EC outside-in signaling induced by cytotoxic lymphocytes, and suggest that these signals may play a role in EC alteration by lymphocyte adhesion.