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Antibacterial activity of mupirocin (pseudomonic acid), a new antibiotic for topical use
Mupirocin (pseudomonic acid A), an antibiotic produced by Pseudomonas fluorescens, showed a high level of activity against staphylococci and streptococciand against certain gram-negative bacteria, but was much less active against most gram- negative bacilli an anaerobes.
High-level mupirocin resistance in Staphylococcus aureus: evidence for two distinct isoleucyl-tRNA synthetases
Results demonstrate that two different IRS enzymes were present in highly mupirocin-resistant S. aureus strains, and in strains expressing intermediate levels of resistance, only a chromosomally encoded IRS which was inhibited less by m upirocin than IRS from fully susceptible strains was detected.
BRL 17421 , a Novel f ,-Lactam Antibiotic , Highly Resistant to , 8-Lactamases , Giving High and Prolonged Serum Levels in Humans
The compound exhibits exceptional stability to a wide range of bacterial /8-lactamases and is active against the majority of Enterobacteriaceae, including strains highly resistant to many of the penicillins and cephalosporins currently available.
In vitro antibacterial properties of BRL 36650, a novel 6 alpha-substituted penicillin
BRL 36650 is a new type of penicillin in which a formamido group has been introduced into the 6 alpha-position of the nucleus. The compound is highly active against aerobic gram-negative bacteria and
BRL 17421, a novel beta-lactam antibiotic, highly resistant to beta-lactamases, giving high and prolonged serum levels in humans
The compound was well tolerated after intramuscular and intravenous administration in volunteers, with no adverse side effects, and was markedly less active against Pseudomonas aeruginosa and Bacteroides fragilis than against the Enterobacteriaceae.
Effect of low concentrations of clavulanic acid on the in-vitro activity of amoxycillin against beta-lactamase-producing Branhamella catarrhalis and Haemophilus influenzae.
It was showed that amoxycillin/clavulanic acid, at concentrations similar to those likely to be achieved in the respiratory tract following oral dosage, was bactericidal in vitro for beta-lactamase-producing isolates of B.catarrhalis and H. influenzae.
R-factor mediated β-Lactamase in Pseudomonas aeruginosa
It is reported that two of the carbenicillin-resistant strains isolated (1822 and 3425) produce a β-lactamase similar to R-factor mediated β-methionine of Escherichia coli strains and dissimilar from typical Ps.
The antimicrobial activity of mupirocin--an update on resistance.
Aminoglycoside-resistant enterococci.
The gentamicin-resistant strains showed variable responses to amoxycillin/aminoglycoside combinations in tests for bactericidal synergy and were generally less sensitive than typical strains of Strep.
Temocillin. In vitro antibacterial activity.
In combination with aminoglycoside antibiotics, temocillin exerted a synergistic or partially synergistic effect (sigma FIC less than or equal to 0.75) against the majority of strains of Pseudomonas aeruginosa tested.