B. Singer

Publications87
h-index31
Citations4,579
Highly Influential Citations56
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Molecular Biology of Mutagens and Carcinogens
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The chemical effects of nucleic acid alkylation and their relation to mutagenesis and carcinogenesis.
  • B. Singer
  • Biology, Chemistry
    Progress in nucleic acid research and molecular…
  • 1975
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Reactions of Directly Acting Agents with Nucleic Acids
TLDR
In this chapter, only directly acting agents will be discussed, with one exception: Dia1kylnitrosamines must undergo only a simple enzymatic step to be reactive, and are included in the section on N-nitroso compounds rather than in Chapters V and VI, which deal with metabolically activated agents.
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Purification of viral RNA by means of bentonite.
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N-nitroso alkylating agents: formation and persistence of alkyl derivatives in mammalian nucleic acids as contributing factors in carcinogenesis.
  • B. Singer
  • Chemistry
    Journal of the National Cancer Institute
  • 1 June 1979
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Site-specific mutagenesis: retrospective and prospective.
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Nucleoside adducts are formed by cooperative reaction of acetaldehyde and alcohols: possible mechanism for the role of ethanol in carcinogenesis.
TLDR
These findings supply a mechanism by which ethanol can be covalently bound to nucleic acids under physiological conditions and are of biological concern because they also occur in dilute aqueous solution.
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All oxygens in nucleic acids react with carcinogenic ethylating agents
TLDR
Oxygen reactivity of single-stranded DNA resembles RNA and the glycosidic bond of O2-alkylpyrimidines is labilised.
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Reconstitution of tobacco mosaic virus. III. Improved methods and the use of mixed nucleic acids.
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O-alkyl pyrimidines in mutagenesis and carcinogenesis: occurrence and significance.
  • B. Singer
  • Chemistry, Medicine
    Cancer research
  • 1 October 1986
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