• Publications
  • Influence
Reactions of Directly Acting Agents with Nucleic Acids
TLDR
In this chapter, only directly acting agents will be discussed, with one exception: Dia1kylnitrosamines must undergo only a simple enzymatic step to be reactive, and are included in the section on N-nitroso compounds rather than in Chapters V and VI, which deal with metabolically activated agents.
Nucleoside adducts are formed by cooperative reaction of acetaldehyde and alcohols: possible mechanism for the role of ethanol in carcinogenesis.
TLDR
These findings supply a mechanism by which ethanol can be covalently bound to nucleic acids under physiological conditions and are of biological concern because they also occur in dilute aqueous solution.
All oxygens in nucleic acids react with carcinogenic ethylating agents
TLDR
Oxygen reactivity of single-stranded DNA resembles RNA and the glycosidic bond of O2-alkylpyrimidines is labilised.
...
...