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Thresholds in cerebral ischemia - the ischemic penumbra.
COMPLETE ARREST of the cerebral circulation leads within seconds to cessation of neuronal electrical activity and within a few minutes to deterioration of the energy state and ion homeostasis.Expand
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Pathophysiology and treatment of focal cerebral ischemia. Part I: Pathophysiology.
This article examines the pathophysiology of lesions caused by focal cerebral ischemia. Ischemia due to middle cerebral artery occlusion encompasses a densely ischemic focus and a less denselyExpand
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Models for studying long‐term recovery following forebrain ischemia in the rat. 2. A 2‐vessel occlusion model
ABSTRACT— A model is described in which transient ischemia is induced in rats anaesthetized with N2O:O2 (70:30) by bilateral carotid artery clamping combined with a lowering of mean arterial bloodExpand
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Neuroprotective Effects of a Novel Nitrone, NXY-059, after Transient Focal Cerebral Ischemia in the Rat
Recent results have demonstrated that the spin trapping agent α-phenyl-N-tert-butyl nitrone (PBN) reduces infarct volume in rats subjected to 2 hours of middle cerebral artery occlusion, even whenExpand
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Calcium in ischemic cell death.
BACKGROUND This review article deals with the role of calcium in ischemic cell death. A calcium-related mechanism was proposed more than two decades ago to explain cell necrosis incurred in cardiacExpand
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Brain Cortical Fatty Acids and Phospholipids During and Following Complete and Severe Incomplete Ischemia
Abstract: To explore the possibility that peroxtdative degradation of brain tissue lipid constituents is an important mechanism of irreversible ischemic damage, we measured cortical fatty acids andExpand
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Differential regulation of mRNAs for nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 in the adult rat brain following cerebral ischemia and hypoglycemic coma.
In situ hybridization was used to study expression of mRNAs for members of the nerve growth factor (NGF) family in the rat brain after 2 and 10 min of forebrain ischemia and 1 and 30 min ofExpand
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Calcium Fluxes, Calcium Antagonists, and Calcium-Related Pathology in Brain Ischemia, Hypoglycemia, and Spreading Depression: A Unifying Hypothesis
It has been commonly assumed that calcium, which normally serves important functions as a membrane stabilizer, metabolic regulator, and sec­ ond messenger, also can mediate anoxic and toxic cellExpand
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Pathophysiology and treatment of focal cerebral ischemia. Part II: Mechanisms of damage and treatment.
  • B. Siesjö
  • Medicine
  • Journal of neurosurgery
  • 1 September 1992
The mechanisms that give rise to ischemic brain damage have not been definitively determined, but considerable evidence exists that three major factors are involved: increases in the intercellularExpand
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Acidosis and ischemic brain damage.
  • B. Siesjö
  • Medicine
  • Neurochemical pathology
  • 1 July 1988
It is now widely accepted that acidosis is an important component of the pathogenetic events that lead to ischemic brain damage. The objective with this article is to recall the evolution of theExpand
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