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The density and distribution of ischemic brain injury in the rat following 2–10 min of forebrain ischemia
SummaryThe density and distribution of brain damage after 2–10 min of cerebral ischemia was studied in the rat. Ischemia was produced by a combination of carotid clamping and hypotension, followed byExpand
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Ischemic penumbra in a model of reversible middle cerebral artery occlusion in the rat
SummaryIt has become increasingly clear that a stroke lesion usually consists of a densely ischemic focus and of perifocal areas with better upheld flow rates. At least in rats and cats, some ofExpand
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Amelioration by cyclosporin A of brain damage in transient forebrain ischemia in the rat
The immunosuppressant drug cyclosporin A (CsA) is considered to be inherently protective in conditions of ischemia, e.g. in hepatic and cardiac tissue. However, investigations of effects of CsA onExpand
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The distribution of hypoglycemic brain damage
SummaryRats were exposed to insulin-induced hypoglycemia resulting in periods of cerebral isoelectricity ranging from 10 to 60 min. After recovery with glucose, they were allowed to wake up andExpand
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The regulation of cerebrospinal fluid pH
The past ten years have witnessed an increasing interest in the regulation of the cerebrospinal fluid (CSF) pH.Part of this interest stems from the fact that the extracellular fluid (ECF) pH in theExpand
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Phosphorylation of Extracellular Signal-Regulated Kinase after Transient Cerebral Ischemia in Hyperglycemic Rats
The present study was undertaken to investigate whether extracellular signal-regulated kinase (ERK) was involved in mediating hyperglycemia-exaggerated cerebral ischemic damage. Phosphorylation ofExpand
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The temporal evolution of hypoglycemic brain damage
SummaryIn the course of a study on the pathogenesis of neuronal necrosis in severe hypoglycemia, the morphological characteristics reflecting reversible and irreversible neuronal lesions wereExpand
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Extra‐ and Intracellular pH in the Brain During Ischaemia, Related to Tissue Lactate Content in Normo‐and Hypercapnic rats
The objective of the present study was to assess the relationship between the amount of lactate accumulated during complete ischaemia and the ensuing changes in extra‐ and intracellular pH (pHe andExpand
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The influence of hypothermia on hypoglycemia-induced brain damage in the rat
SummaryThe effects of hypothermia on hypoglycemic brain damage were studied in rats after a 30-min period of hypoglycemic coma, defined as cessation of spontaneous EEG activity. The rats were eitherExpand
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