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Sepsis-induced long-term immune paralysis – results of a descriptive, explorative study
BackgroundLong-lasting impairment of the immune system is believed to be the underlying reason for delayed deaths after surviving sepsis. We tested the hypothesis of persisting changes to the immune… Expand
Binding protein for human growth hormone: effects of age and weight.
In human serum, a specific binding protein with high affinity for human growth hormone (GHBP) is found which is identical to the extracellular portion of the hepatic GH receptor. GHBP is assessed by… Expand
The serum growth hormone-binding protein is reduced in young patients with insulin-dependent diabetes mellitus.
Despite elevated serum concentrations of GH, longitudinal growth is stunted in a considerable number of children and adolescents with insulin-dependent diabetes mellitus (IDDM). To elucidate, whether… Expand
Are there new approaches for diagnosis, therapy guidance and outcome prediction of sepsis?
- D. Kojic, B. Siegler, +5 authors T. Brenner
- World journal of experimental medicine
- 20 May 2015
Beside many efforts to improve outcome, sepsis is still one of the most frequent causes of death in critically ill patients. It is the most common condition with high mortality in intensive care… Expand
The Glyoxalase System and Methylglyoxal-Derived Carbonyl Stress in Sepsis: Glycotoxic Aspects of Sepsis Pathophysiology
- T. Schmoch, F. Uhle, +5 authors T. Brenner
- Biology, Chemistry
- International journal of molecular sciences
- 1 March 2017
Sepsis remains one of the leading causes of death in intensive care units. Although sepsis is caused by a viral, fungal or bacterial infection, it is the dysregulated generalized host response that… Expand
Sepsis Induces Specific Changes in Histone Modification Patterns in Human Monocytes
Background Sepsis is a global burden and the primary cause of death in intensive care units worldwide. The pathophysiological changes induced by the host’s systemic inflammatory response to infection… Expand
[Use of biomarkers in sepsis. Update and perspectives].
Sepsis and related complications are a challenge for intensive care medicine. Despite many advances in antibiotic therapy sepsis remains one of the most common diseases of patients in intensive care… Expand
Differential effects of C1q/tumor necrosis factor-related proteins on cardiomyocyte glucose metabolism
Why a second look might be worth it: immuno-modulatory therapies in the critically ill patient.
- B. Siegler, T. Brenner, F. Uhle, S. Weiterer, M. Weigand, S. Hofer
- Journal of thoracic disease
- 13 May 2016
Sepsis and septic shock are associated with high mortality rates and remain a serious menace for the critically ill patient. Concurrent activation of pro- and anti-inflammatory pathways and an… Expand
The immunosuppressive face of sepsis early on intensive care unit—A large-scale microarray meta-analysis
Background Sepsis is defined as a life-threatening condition, resulting from a dysregulated and harmful response of the hosts’ immune system to infection. Apart from this, the (over-)compensating… Expand