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Replication Fork Stability Confers Chemoresistance in BRCA-deficient Cells
Cells deficient in the Brca1 and Brca2 genes have reduced capacity to repair DNA double-strand breaks by homologous recombination and consequently are hypersensitive to DNA-damaging agents, including… Expand
Structural Basis for FEN-1 Substrate Specificity and PCNA-Mediated Activation in DNA Replication and Repair
Flap EndoNuclease-1 (FEN-1) and the processivity factor proliferating cell nuclear antigen (PCNA) are central to DNA replication and repair. To clarify the molecular basis of FEN-1 specificity and… Expand
Human Flap Endonuclease Structures, DNA Double-Base Flipping, and a Unified Understanding of the FEN1 Superfamily
Flap endonuclease (FEN1), essential for DNA replication and repair, removes RNA and DNA 5' flaps. FEN1 5' nuclease superfamily members acting in nucleotide excision repair (XPG), mismatch repair… Expand
Structure of the DNA Repair and Replication Endonuclease and Exonuclease FEN-1 Coupling DNA and PCNA Binding to FEN-1 Activity
Flap endonuclease (FEN-1) removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. The crystal structure of Pyrococcus furiosus… Expand
PprI: a general switch responsible for extreme radioresistance of Deinococcus radiodurans.
- Y. Hua, I. Narumi, +4 authors B. Shen
- Biology, Medicine
- Biochemical and biophysical research…
- 27 June 2003
Deinococcus radiodurans exhibits an extraordinary ability to withstand the lethal and mutagenic effects of DNA damaging agents, particularly, ionizing radiation. Available evidence indicates that… Expand
Removal of Oxidative DNA Damage via FEN1-Dependent Long-Patch Base Excision Repair in Human Cell Mitochondria
ABSTRACT Repair of oxidative DNA damage in mitochondria was thought limited to short-patch base excision repair (SP-BER) replacing a single nucleotide. However, certain oxidative lesions cannot be… Expand
CtIP maintains stability at common fragile sites and inverted repeats by end resection-independent endonuclease activity.
Chromosomal rearrangements often occur at genomic loci with DNA secondary structures, such as common fragile sites (CFSs) and palindromic repeats. We developed assays in mammalian cells that revealed… Expand
Functional analysis of point mutations in human flap endonuclease-1 active site.
Human flap endonuclease-1 (hFEN-1) is highly homologous to human XPG, Saccharomyces cerevisiae RAD2 and S.cerevisiae RTH1 and shares structural and functional similarity with viral exonucleases such… Expand
Novel function of the flap endonuclease 1 complex in processing stalled DNA replication forks
Restarting stalled replication forks partly depends on the break‐induced recombination pathway, in which a DNA double‐stranded break (DSB) is created on the stalled replication fork to initiate the… Expand
Activation of nuclear factor kappaB in radioresistance of TP53-inactive human keratinocytes.
Many tumors show a mutant or inactive tumor suppressor p53 (TP53) status, and TP53 in the tumor-carrying human papillomavirus (HPV) may be dysfunctional because of inhibition by the viral protein HPV… Expand