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Female genital-tract HIV load correlates inversely with Lactobacillus species but positively with bacterial vaginosis and Mycoplasma hominis.
BACKGROUND Bacterial vaginosis (BV) is associated with human immunodeficiency virus (HIV) acquisition. We examined the association between BV and BV-associated bacteria and expression of HIV in theExpand
Effects of bacterial vaginosis and other genital infections on the natural history of human papillomavirus infection in HIV-1-infected and high-risk HIV-1-uninfected women.
BV and TV infection may increase the risk of acquisition (or reactivation) of HPV infection, as is consistent with hypotheses that the local cervicovaginal milieu plays a role in susceptibility to HPV infection. Expand
Induction of tumor necrosis factor- alpha secretion and toll-like receptor 2 and 4 mRNA expression by genital mucosal fluids from women with bacterial vaginosis.
These experiments show that genital mucosal fluids and certain bacteria from women with BV stimulate TNF- alpha secretion and TLR4 mRNA expression, suggesting mechanisms whereby BV affects pregnancy and HIV transmission. Expand
Susceptibility of HIV-1 plasma virus to complement-mediated lysis. Evidence for a role in clearance of virus in vivo.
The results of this study strongly suggest that C is activated by a portion of plasma virus in vivo due to the binding of Ab, and the resultant opsonization plus subsequent lysis may be important routes of clearance and destruction of Plasma virus in infected persons. Expand
Utility of Amsel Criteria, Nugent Score, and Quantitative PCR for Gardnerella vaginalis, Mycoplasma hominis, and Lactobacillus spp. for Diagnosis of Bacterial Vaginosis in Human Immunodeficiency
PCR quantification of G. vaginalis and M. hominis from CVL is significantly more sensitive than Amsel criteria for diagnosing BV, and Utilizing all three log10 bacterial counts in the model improved the sensitivity and specificity to 83% and 78%, respectively, in comparison with Nugent score. Expand
Age-related immune dysfunction in health and in human immunodeficiency virus (HIV) disease: association of age and HIV infection with naive CD8+ cell depletion, reduced expression of CD28 on CD8+
Because of their common association with age and HIV disease, naive CD8(+) cell depletion, diminished CD28 expression on CD8 (+) cells, and reduced thymic volumes are possible correlates of the interaction of age with HIV disease. Expand
Bacterial vaginosis-associated microflora isolated from the female genital tract activates HIV-1 expression.
Bacterial vaginosis-associated microflora can enhance HIV-1 transcription and replication and identify M. hominis as a potential source for HIF activity, which may increase genital tract viral load, potentially contributing to HIV transmission. Expand
Immunologic and virologic evaluation after influenza vaccination of HIV‐1‐infected patients
It is indicated that immune stimulation resulting from influenza vaccination did not significantly change the levels of plasma virus, CD4 cell counts, or activation‐induced apoptosis in HIV‐infected individuals, although an increase in the T‐cell response to influenza and spontaneous apoptosis was observed in the > 300 and < 300 CD4 groups, respectively. Expand