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S‐layers: principles and applications
Monomolecular arrays of protein or glycoprotein subunits forming surface layers (S‐layers) are one of the most commonly observed prokaryotic cell envelope components and revealed considerable application potential in (nano)biotechnology, biomimetics, biomedicine and synthetic biology.
S-layers as a tool kit for nanobiotechnological applications.
The basic principles of S-layer proteins and the application potential ofS-layers in nanobiotechnology and biomimetics including life and nonlife sciences are reviewed.
Effect of temperature and phase transition on oxidation resistance of low density lipoprotein.
It is demonstrated that temperature exerts a clear effect in the Cu(2+)-mediated LDL oxidation, with a strong decrease in lag time and a notable increase in the rate of propagation, suggesting that the core melting point of the LDL has no or only a minor effect on these oxidation indices.
Characterization of CurcuEmulsomes: nanoformulation for enhanced solubility and delivery of curcumin
Incorporation of curcumin into emulsomes results in water-soluble and stableCurcuEmulsome nanoformulations, which highlight the potential of the system for the delivery of lipophilic drugs and high degree of compatibility, prolonged release profile and tailoring properties feature Curcu Emulsomes for further therapeutic applications in vivo.
The mechanism of action of phenylalanine ammonia-lyase: the role of prosthetic dehydroalanine.
  • B. Schuster, J. Rétey
  • Biology, Chemistry
    Proceedings of the National Academy of Sciences…
  • 29 August 1995
Results suggest a mechanism in which the crucial step is an electrophilic attack of the prosthetic group at position 2 or 6 of the phenyl group in the resulting carbenium ion, which completes the catalytic cycle.
S-layer coated emulsomes as potential nanocarriers.
In vitro cell culture studies reveal that S-layer coated emulsomes can be uptaken by human liver carcinoma cells without showing any significant cytotoxicity over a wide range of concentrations.
S-layers as patterning elements for application in nanobiotechnology.
Functionalized S-layer proteins that maintain their ability to self-assemble have led to new affinity matrices, diagnostic tools, vaccines or biocompatible surfaces, as well as to biological templating or specific biomineralisation strategies at surfaces.
S‐Layers as a basic building block in a molecular construction kit
This work has shown that monomolecular lattices in S‐Layer lattices can be exploited as scaffolding and patterning elements for generating more complex supramolecular assemblies and structures, as required for life and nonlife science applications.