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- Publications
- Influence
Probing the free-energy surface for protein folding with single-molecule fluorescence spectroscopy
- B. Schuler, E. A. Lipman, W. Eaton
- Chemistry, Medicine
- Nature
- 17 October 2002
Protein folding is inherently a heterogeneous process because of the very large number of microscopic pathways that connect the myriad unfolded conformations to the unique conformation of the native… Expand
Neural activity associated with distinguishing concurrent auditory objects.
- C. Alain, B. Schuler, K. McDonald
- Medicine, Physics
- The Journal of the Acoustical Society of America
- 11 February 2002
The neural processes underlying concurrent sound segregation were examined by using event-related brain potentials. Participants were presented with complex sounds comprised of multiple harmonics,… Expand
Consistent View of Polypeptide Chain Expansion in Chemical Denaturants from Multiple Experimental Methods.
- A. Borgia, Wenwei Zheng, +9 authors B. Schuler
- Chemistry, Medicine
- Journal of the American Chemical Society
- 1 September 2016
There has been a long-standing controversy regarding the effect of chemical denaturants on the dimensions of unfolded and intrinsically disordered proteins: A wide range of experimental techniques… Expand
Polymer scaling laws of unfolded and intrinsically disordered proteins quantified with single-molecule spectroscopy
- H. Hofmann, Andrea Soranno, A. Borgia, K. Gast, D. Nettels, B. Schuler
- Chemistry, Medicine
- Proceedings of the National Academy of Sciences
- 14 September 2012
The dimensions of unfolded and intrinsically disordered proteins are highly dependent on their amino acid composition and solution conditions, especially salt and denaturant concentration. However,… Expand
Quantifying internal friction in unfolded and intrinsically disordered proteins with single-molecule spectroscopy
- Andrea Soranno, Brigitte Buchli, +7 authors B. Schuler
- Chemistry, Medicine
- Proceedings of the National Academy of Sciences
- 6 April 2012
Internal friction, which reflects the “roughness” of the energy landscape, plays an important role for proteins by modulating the dynamics of their folding and other conformational changes. However,… Expand
Ultrafast dynamics of protein collapse from single-molecule photon statistics
- D. Nettels, I. Gopich, A. Hoffmann, B. Schuler
- Chemistry, Medicine
- Proceedings of the National Academy of Sciences
- 20 February 2007
We use the statistics of photon emission from single molecules to probe the ultrafast dynamics of an unfolded protein via Förster resonance energy transfer. Global reconfiguration of the chain occurs… Expand
Extreme disorder in an ultrahigh-affinity protein complex
- A. Borgia, Madeleine B Borgia, +10 authors B. Schuler
- Medicine
- Nature
- 1 March 2018
Molecular communication in biology is mediated by protein interactions. According to the current paradigm, the specificity and affinity required for these interactions are encoded in the precise… Expand
Charge interactions can dominate the dimensions of intrinsically disordered proteins
- S. Müller-Späth, Andrea Soranno, +5 authors B. Schuler
- Chemistry, Medicine
- Proceedings of the National Academy of Sciences
- 16 July 2010
Many eukaryotic proteins are disordered under physiological conditions, and fold into ordered structures only on binding to their cellular targets. Such intrinsically disordered proteins (IDPs) often… Expand
Two-state folding observed in individual protein molecules.
- Elizabeth A Rhoades, M. Cohen, B. Schuler, G. Haran
- Chemistry, Medicine
- Journal of the American Chemical Society
- 21 October 2004
The folding dynamics of small proteins are often described in terms of a simple two-state kinetic model. Within this notion, the behavior of individual molecules is expected to be stochastic, with a… Expand
Mapping protein collapse with single-molecule fluorescence and kinetic synchrotron radiation circular dichroism spectroscopy
- A. Hoffmann, A. Kane, +8 authors B. Schuler
- Materials Science, Chemistry
- Proceedings of the National Academy of Sciences
- 8 November 2006
We have used the combination of single-molecule Förster resonance energy transfer and kinetic synchrotron radiation circular dichroism experiments to probe the conformational ensemble of the… Expand