• Publications
  • Influence
Effect of unmodified triple helix‐forming oligodeoxyribonucleotide targeted to human multidrug‐resistance gene mdr1 in MDR cancer cells
The human mdr1 gene encodes a transmembrane glycoprotein the over‐expression of which is associated with development of multidrug resistance in human tumor cells. A negative modulation of human mdr1Expand
  • 42
  • 4
Modulation of human neutrophil function by C-reactive protein.
Investigation of the effect of C-reactive protein (CRP), an acute-phase reactant, on the functional capacities of human neutrophils was carried out as the basis for elucidating the biologicalExpand
  • 45
  • 3
Bortezomib arrests the proliferation of hepatocellular carcinoma cells HepG2 and JHH6 by differentially affecting E2F1, p21 and p27 levels.
Despite the broad anti-tumour potential of the proteasome inhibitor bortezomib, partial information is available with regard to its effects on hepatocellular carcinoma (HCC) cells. Here we studiedExpand
  • 61
  • 3
Bortezomib effect on E2F and cyclin family members in human hepatocellular carcinoma cell lines.
AIM To evaluate the effects of the proteasome inhibitor bortezomib (BZB) on E2Fs and related genes in hepatocellular carcinoma (HCC) cells. METHODS The mRNA levels of the E2F family membersExpand
  • 25
  • 3
The expression levels of the translational factors eEF1A 1/2 correlate with cell growth but not apoptosis in hepatocellular carcinoma cell lines with different differentiation grade.
Despite the involvement of the elongation factors eEF1A (eEF1A1 and eEF1A2) in the development of different cancers no information is available on their possible contribution to the biology ofExpand
  • 60
  • 2
Interaction of G‐rich GT oligonucleotides with nuclear‐associated eEF1A is correlated with their antiproliferative effect in haematopoietic human cancer cell lines
G‐rich GT oligonucleotides with a different content of G clusters have been evaluated for their ability to exert cytotoxicity and to bind to nuclear‐associated proteins in T‐lymphoblast CCRF‐CEMExpand
  • 21
  • 2
Effects of E2F1-cyclin E1-E2 circuit down regulation in hepatocellular carcinoma cells.
BACKGROUND No effective therapy is available for hepatocellular carcinoma. To identify novel therapeutic strategies, we explored the effects of the depletion of E2F1, cyclin E1-E2 whoseExpand
  • 29
  • 2
Human cancer cell lines growth inhibition by GTn oligodeoxyribonucleotides recognizing single-stranded DNA-binding proteins.
Oligonucleotides can specifically target not only nucleic acids but also proteins. Some proteins recognizing oligonucleotides in a sequence-specific manner have been related to cancer transformationExpand
  • 21
  • 1
Effect of oligomer length and base substitutions on the cytotoxic activity and specific nuclear protein recognition of GTn oligonucleotides in the human leukemic CCRF-CEM cell line.
We have identified phosphodiester oligonucleotides composed of G and T bases, named GTn, which are able to inhibit the cellular growth of human cancer cell lines by recognising specific nuclearExpand
  • 10
  • 1
Novel hepatocellular carcinoma molecules with prognostic and therapeutic potentials.
Hepatocellular carcinoma (HCC), the predominant form of primary liver cancer, is the sixth most common cancer worldwide and the third leading cause of cancer-related death. The difficulty to diagnoseExpand
  • 61
  • 1