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Maximal perfusion of skeletal muscle in man.
TLDR
The magnitude of perfusion observed during intense exercise indicates that the vascular bed of skeletal muscle is not a limiting factor for oxygen transport, and muscle blood flow is closely related to the oxygen demand of the exercising muscles. Expand
Human circulatory and thermoregulatory adaptations with heat acclimation and exercise in a hot, dry environment.
TLDR
It is concluded that the high core temperature per se, and not circulatory failure, is the critical factor for the exhaustion during exercise in heat stress. Expand
Diet, muscle glycogen and physical performance.
TLDR
It has been shown that the glycogen content and, consequently, the long-term work capacity can be appreciably varied by instituting different diets after glycogen depletion. Expand
Exercise induces transient transcriptional activation of the PGC‐1α gene in human skeletal muscle
TLDR
It is demonstrated that exercise induces a dramatic transient increase in PGC‐1α transcription and mRNA content in human skeletal muscle, consistent with its role as a transcriptional coactivator, and suggest that PGC•1α may coordinate the activation of metabolic genes in human muscle in response to exercise. Expand
Evidence for prescribing exercise as therapy in chronic disease
TLDR
The evidence for prescribing exercise therapy in the treatment of metabolic syndrome‐related disorders (insulin resistance, type 2 diabetes, dyslipidemia, hypertension, obesity), heart and pulmonary diseases, muscle, bone and joint diseases, and cancer, depression, asthma and type 1 diabetes is presented. Expand
Production of interleukin‐6 in contracting human skeletal muscles can account for the exercise‐induced increase in plasma interleukin‐6
TLDR
It is suggested that IL‐6 produced by skeletal contracting muscle contributes to the maintenance of glucose homeostasis during prolonged exercise. Expand
Transcriptional regulation of gene expression in human skeletal muscle during recovery from exercise.
TLDR
It is demonstrated that exercise induces transient increases in transcription of metabolic genes in human skeletal muscle, and the findings suggest that the cumulative effects of transient rises in transcription during recovery from consecutive bouts of exercise may represent the underlying kinetic basis for the cellular adaptations associated with exercise training. Expand
Determinants of maximal oxygen uptake in severe acute hypoxia.
TLDR
Three main mechanisms account for the reduction of VO2 max in severe acute hypoxia: reduction of PiO2, impairment of pulmonary gas exchange, and 3) reduction of maximal cardiac output and peak leg blood flow, each explaining about one-third of the loss inVO2 max. Expand
Skeletal muscle substrate utilization during submaximal exercise in man: effect of endurance training.
TLDR
The findings suggest that FFA uptake in exercising muscle is a saturable process and that the transport capacity is enhanced by training, and that a shift towards a larger fat combustion occurred with endurance training. Expand
The effect of ageing and immobilization on structure and function of human skeletal muscle fibres.
TLDR
Myosin concentration is a major determinant of the lower Po/CSA of single fibres in ageing and especially following immobilization, whereas immobilization is associated with higher Vo in the absence of a change in myosin function. Expand
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