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Maximal perfusion of skeletal muscle in man.
The magnitude of perfusion observed during intense exercise indicates that the vascular bed of skeletal muscle is not a limiting factor for oxygen transport, and muscle blood flow is closely related to the oxygen demand of the exercising muscles.
Human circulatory and thermoregulatory adaptations with heat acclimation and exercise in a hot, dry environment.
- B. Nielsen, J. Hales, S. Strange, N. Christensen, J. Warberg, B. Saltin
- BiologyJournal of Physiology
It is concluded that the high core temperature per se, and not circulatory failure, is the critical factor for the exhaustion during exercise in heat stress.
Diet, muscle glycogen and physical performance.
- J. Bergström, L. Hermansen, E. Hultman, B. Saltin
- BiologyActa Physiologica Scandinavica
- 1 October 1967
It has been shown that the glycogen content and, consequently, the long-term work capacity can be appreciably varied by instituting different diets after glycogen depletion.
Exercise induces transient transcriptional activation of the PGC‐1α gene in human skeletal muscle
It is demonstrated that exercise induces a dramatic transient increase in PGC‐1α transcription and mRNA content in human skeletal muscle, consistent with its role as a transcriptional coactivator, and suggest that PGC•1α may coordinate the activation of metabolic genes in human muscle in response to exercise.
Exercise as medicine – evidence for prescribing exercise as therapy in 26 different chronic diseases
This review provides the reader with the up‐to‐date evidence‐based basis for prescribing exercise as medicine in the treatment of 26 different diseases: psychiatric diseases (depression, anxiety,…
Evidence for prescribing exercise as therapy in chronic disease
The evidence for prescribing exercise therapy in the treatment of metabolic syndrome‐related disorders (insulin resistance, type 2 diabetes, dyslipidemia, hypertension, obesity), heart and pulmonary diseases, muscle, bone and joint diseases, and cancer, depression, asthma and type 1 diabetes is presented.
Production of interleukin‐6 in contracting human skeletal muscles can account for the exercise‐induced increase in plasma interleukin‐6
- A. Steensberg, G. Hall, T. Osada, M. Sacchetti, B. Saltin, B. Pedersen
- BiologyJournal of Physiology
- 1 November 2000
It is suggested that IL‐6 produced by skeletal contracting muscle contributes to the maintenance of glucose homeostasis during prolonged exercise.
Function, morphology and protein expression of ageing skeletal muscle: a cross-sectional study of elderly men with different training backgrounds.
The results seem to suggest that strength training can counteract the age-related changes in function and morphology of the ageing human skeletal muscle.
Determinants of maximal oxygen uptake in severe acute hypoxia.
- J. Calbet, R. Boushel, G. Rådegran, H. Søndergaard, P. Wagner, B. Saltin
- Biology, MedicineAmerican Journal of Physiology. Regulatory…
- 1 February 2003
Three main mechanisms account for the reduction of VO2 max in severe acute hypoxia: reduction of PiO2, impairment of pulmonary gas exchange, and 3) reduction of maximal cardiac output and peak leg blood flow, each explaining about one-third of the loss inVO2 max.
Transcriptional regulation of gene expression in human skeletal muscle during recovery from exercise.
- H. Pilegaard, G. Ordway, B. Saltin, P. Neufer
- BiologyAmerican Journal of Physiology. Endocrinology and…
- 1 October 2000
It is demonstrated that exercise induces transient increases in transcription of metabolic genes in human skeletal muscle, and the findings suggest that the cumulative effects of transient rises in transcription during recovery from consecutive bouts of exercise may represent the underlying kinetic basis for the cellular adaptations associated with exercise training.