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Developmental and regional expression in the rat brain and functional properties of four NMDA receptors
Recombinant binary NR1-NR2 channels show comparable Ca2+ permeabilities, but marked differences in voltage-dependent Mg2+ block and in offset decay time constants, which provide a basis for NMDA channel heterogeneity in the brain. Expand
Regulation of Synaptic Efficacy by Coincidence of Postsynaptic APs and EPSPs
In dual whole-cell voltage recordings from pyramidal neurons, the coincidence of post Synaptic action potentials and unitary excitatory postsynaptic potentials was found to induce changes in EPSPs. Expand
Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches
Abstract1.The extracellular patch clamp method, which first allowed the detection of single channel currents in biological membranes, has been further refined to enable higher current resolution,Expand
Mechanism of anion permeation through channels gated by glycine and gamma‐aminobutyric acid in mouse cultured spinal neurones.
The ion‐selective and ion transport properties of glycine receptor and gamma‐aminobutyric acid receptor channels in the soma membrane of mouse spinal cord neurones were investigated using the whole‐cell, cell‐attached and outside‐out patch versions of the patch‐clamp technique, indicating that GlyR and GABAR channels are multi‐conductance‐state channels. Expand
Heteromeric NMDA Receptors: Molecular and Functional Distinction of Subtypes
Molecular cloning identified three complementary DNA species of rat brain, encoding NMDA receptor subunits NMDAR2A (NR2A), NR2B, and NR2C, which are 55 to 70% ientical in sequence, and these are structurally related, with less than 20% sequence identity, to other excitatory amino acid receptor sub Units. Expand
Relative abundance of subunit mRNAs determines gating and Ca2+ permeability of AMPA receptors in principal neurons and interneurons in rat CNS
Analysis of AMPARs in principal neurons and interneurons of hippocampus and neocortex and in auditory relay neurons and Bergmann glial cells indicates that the GluR-B subunit in its flip version determines formation of receptors with relatively slow gating, whereas the GLUR-D subunit promotes assembly of more rapidly gated receptors. Expand
Physiology and anatomy of synaptic connections between thick tufted pyramidal neurones in the developing rat neocortex.
Dual voltage recordings were made from pairs of adjacent, synaptically connected thick tufted layer 5 pyramidal neurones in brain slices of young rat (14‐16 days) somatosensory cortex to examine the physiological properties of unitary EPSPs and the axonal and dendritic anatomy of both projecting and target neurones was uniform. Expand
A new cellular mechanism for coupling inputs arriving at different cortical layers
The coincidence of a single back-propagating action potential with a subthreshold distal excitatory postsynaptic potential to evoke a burst of axonal action potentials represents a new mechanism by which the main cortical output neurons can associate inputs arriving at different cortical layers. Expand
Quantal components of unitary EPSCs at the mossy fibre synapse on CA3 pyramidal cells of rat hippocampus.
Five of nine EPSC peak amplitude distributions were judged to be quantal, suggesting that extracellular stimulation was focal, and that the stimulus‐evoked EPSCs were unitary. Expand
Interaction of sensory responses with spontaneous depolarization in layer 2/3 barrel cortex
Surprisingly, whisker deflections evoked fewer action potentials during the spontaneous depolarizations despite neurons being closer to threshold, and the ongoing spontaneous activity regulates the amplitude and the time-dependent spread of the sensory response in layer 2/3 barrel cortex. Expand