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Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors
Good bacteria help fight cancer Resident gut bacteria can affect patient responses to cancer immunotherapy (see the Perspective by Jobin). Routy et al. show that antibiotic consumption is associated… Expand
Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors
The therapeutic efficacy of anticancer chemotherapies may depend on dendritic cells (DCs), which present antigens from dying cancer cells to prime tumor-specific interferon-γ (IFN-γ)–producing T… Expand
Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells.
- F. Chalmin, S. Ladoire, +20 authors F. Ghiringhelli
- Biology, Medicine
- The Journal of clinical investigation
- 1 February 2010
Myeloid-derived suppressor cells (MDSCs) have been identified in humans and mice as a population of immature myeloid cells with the ability to suppress T cell activation. They accumulate in… Expand
Interleukin-17 is a negative regulator of established allergic asthma
- S. Schnyder-Candrian, D. Togbé, +6 authors B. Schnyder
- The Journal of experimental medicine
- 27 November 2006
T helper (Th)17 cells producing interleukin (IL)-17 play a role in autoimmune and allergic inflammation. Here, we show that IL-23 induces IL-17 in the lung and IL-17 is required during antigen… Expand
The Intestinal Microbiota Modulates the Anticancer Immune Effects of Cyclophosphamide
The Microbiota Makes for Good Therapy The gut microbiota has been implicated in the development of some cancers, such as colorectal cancer, but—given the important role our intestinal habitants play… Expand
Alternating electric fields arrest cell proliferation in animal tumor models and human brain tumors
- E. Kirson, V. Dbalý, +13 authors Y. Palti
- Proceedings of the National Academy of Sciences
- 12 June 2007
We have recently shown that low intensity, intermediate frequency, electric fields inhibit by an anti-microtubule mechanism of action, cancerous cell growth in vitro. Using implanted electrodes,… Expand
CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands
Complex interactions between the host and the gut microbiota govern intestinal homeostasis but remain poorly understood. Here we reveal a relationship between gut microbiota and caspase recruitment… Expand
Activation of invariant NKT cells by toll-like receptor 9-stimulated dendritic cells requires type I interferon and charged glycosphingolipids.
Invariant natural killer T (iNKT) cells are a subset of innate lymphocytes that recognize lipid antigens in the context of CD1d and mediate potent immune regulatory functions via the rapid production… Expand
Extracellular ATP is a danger signal activating P2X7 receptor in lung inflammation and fibrosis.
- Nicolas Riteau, P. Gasse, +9 authors I. Couillin
- American journal of respiratory and critical care…
- 15 September 2010
RATIONALE Pulmonary fibrosis is a devastating as yet untreatable disease. We previously investigated the endogenous mediators released on lung injury and showed that uric acid is a danger signal… Expand
Stat3 and Gfi-1 transcription factors control Th17 cell immunosuppressive activity via the regulation of ectonucleotidase expression.
Although Th17 cells are known to promote tissue inflammation and autoimmunity, their role during cancer progression remains elusive. Here, we showed that in vitro Th17 cells generated with the… Expand