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Ion mobility–mass spectrometry analysis of large protein complexes
Here we describe a detailed protocol for both data collection and interpretation with respect to ion mobility–mass spectrometry analysis of large protein assemblies. Ion mobility is a technique thatExpand
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Collision cross sections of proteins and their complexes: a calibration framework and database for gas-phase structural biology.
Collision cross sections in both helium and nitrogen gases were measured directly using a drift cell with RF ion confinement inserted within a quadrupole/ion mobility/time-of-flight hybrid massExpand
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Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease.
In recent years, small protein oligomers have been implicated in the aetiology of a number of important amyloid diseases, such as type 2 diabetes, Parkinson's disease and Alzheimer's disease. As aExpand
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Protein complexes in the gas phase: technology for structural genomics and proteomics.
A review on the application of mass spectrometry (MS) to the upper levels of protein organization is presented. A description on the processes of generating, transmitting, and analyzing ions formedExpand
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Evidence for Macromolecular Protein Rings in the Absence of Bulk Water
We have examined the architecture of a protein complex in the absence of bulk water. By determining collision cross sections of assemblies of the trp RNA binding protein, TRAP, we established thatExpand
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Mass spectrometry: come of age for structural and dynamical biology.
Over the past two decades, mass spectrometry (MS) has emerged as a bone fide approach for structural biology. MS can inform on all levels of protein organization, and enables quantitative assessmentsExpand
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Ion mobility–mass spectrometry: a new paradigm for proteomics
Abstract Matrix-assisted laser desorption/ionization (MALDI) coupled with ion mobility–mass spectrometry (IM–MS) provides a rapid (μs–ms) means for the two-dimensional (2D) separation of complexExpand
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Ion Mobility Mass Spectrometry.
for more complex analysers for automated sample processing and plant control. The separation time will continue to decrease; in the past there has been limited interest in fast separations but thisExpand
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Insights into antiamyloidogenic properties of the green tea extract (−)-epigallocatechin-3-gallate toward metal-associated amyloid-β species
Despite the significance of Alzheimer’s disease, the link between metal-associated amyloid-β (metal–Aβ) and disease etiology remains unclear. To elucidate this relationship, chemical tools capable ofExpand
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Alternate dissociation pathways identified in charge-reduced protein complex ions.
Tandem mass spectrometry (MS) of large protein complexes has proven to be capable of assessing the stoichiometry, connectivity, and structural details of multiprotein assemblies. While the utility ofExpand
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