• Publications
  • Influence
Managing cough as a defense mechanism and as a symptom. A consensus panel report of the American College of Chest Physicians.
Chest O'Byrne, RH Poe, UB Prakash, MR Pratter and BK Rubin RS Irwin, LP Boulet, MM Cloutier, R Fuller, PM Gold, V Hoffstein, AJ Ing, FD McCool, P of the American College of Chest Physicians ManagingExpand
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Mechanisms of Action and Clinical Application of Macrolides as Immunomodulatory Medications
SUMMARY Macrolides have diverse biological activities and an ability to modulate inflammation and immunity in eukaryotes without affecting homeostatic immunity. These properties have led to theirExpand
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Mucins, mucus, and sputum.
Normal airway mucus lines the epithelial surface and provides an important innate immune function by detoxifying noxious molecules and by trapping and removing pathogens and particulates from theExpand
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Familial pulmonary alveolar proteinosis caused by mutations in CSF2RA
Primary pulmonary alveolar proteinosis (PAP) is a rare syndrome characterized by accumulation of surfactant in the lungs that is presumed to be mediated by disruption of granulocyte/macrophageExpand
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Problems with inhaler use: a call for improved clinician and patient education.
Patient education is a critical factor in the use and misuse of medication inhalers. Inhalers represent advanced technology that is considered so easy to use that many patients and clinicians do notExpand
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Macrolide antibiotics as immunomodulatory medications: proposed mechanisms of action.
Macrolide antibiotics administered in sub-antimicrobial doses improve pulmonary function and decrease exacerbation frequency for persons with diffuse panbronchiolitis or cystic fibrosis. Data alsoExpand
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Plastic bronchitis: new insights and a classification scheme.
Plastic bronchitis is a rare disease in which there is the formation of large gelatinous or rigid branching airway casts. The history of the disease is reviewed and a classification system isExpand
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Mucolytics, expectorants, and mucokinetic medications.
  • B. Rubin
  • Medicine
  • Respiratory care
  • 1 July 2007
In health, the airways are lined by a layer of protective mucus gel that sits atop a watery periciliary fluid. Mucus is an adhesive, viscoelastic gel, the biophysical properties of which are largelyExpand
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Hereditary pulmonary alveolar proteinosis: pathogenesis, presentation, diagnosis, and therapy.
RATIONALE We identified a 6-year-old girl with pulmonary alveolar proteinosis (PAP), impaired granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor function, and increased GM-CSF. Expand
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AARC Clinical Practice Guideline: Effectiveness of Nonpharmacologic Airway Clearance Therapies in Hospitalized Patients
Airway clearance therapy (ACT) is used in a variety of settings for a variety of ailments. These guidelines were developed from a systematic review with the purpose of determining whether the use ofExpand
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