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Zingiberis rhizoma: a comprehensive review on the ginger effect and efficacy profiles.
A comprehensive review of the literature to summarize the pharmacological and clinical effects of this popular plant material found ginger exerts in vitro antioxidative, antitumorigenic and immunomodulatory effects and is an effective antimicrobial and antiviral agent. Expand
An overview on biological mechanisms of PPARs.
Structural features of PPARs, their gene transcription mechanisms and recent developments in the discovery of their biological functions are reviewed. Expand
Effect of St John's wort and ginseng on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects.
St John's wort significantly induced the apparent clearance of both S-warfarin and R-warFarin, which in turn resulted in a significant reduction in the pharmacological effect of rac-war Farin, and Coadministration of warfarin with ginseng did not affect the pharmacokinetics or pharmacodynamics of either S- Warfarin or R-Warfarin. Expand
The Brain Exocyst Complex Interacts with RalA in a GTP-dependent Manner
Ral is a small GTPase involved in critical cellular signaling pathways. The two isoforms, RalA and RalB, are widely distributed in different tissues, with RalA being enriched in brain. The bestExpand
Effect of ginkgo and ginger on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects.
Ginkgo and ginger at recommended doses do not significantly affect clotting status, the pharmacokinetics or pharmacodynamics of warfarin in healthy subjects and these herbs did not affect CYP2C9 activity. Expand
A casein kinase I motif present in the cytoplasmic domain of members of the tumour necrosis factor ligand family is implicated in ‘reverse signalling’
It is predicted that this casein kinase I (CKI) motif is phosphorylated in other TNF ligand members, and that it represents a new insight into the mechanism of ‘reverse signalling’ in this cytokine family. Expand
Pharmacodynamic interaction of warfarin with cranberry but not with garlic in healthy subjects
The aim of this study was to investigate the possible impact of two commonly used herbal medicines, garlic and cranberry, on the pharmacokinetics and pharmacodynamics of warfarin in healthy male subjects. Expand
Increased sensitivity of desensitized TRPV1 by PMA occurs through PKCepsilon-mediated phosphorylation at S800.
PCepsilon and S800 are identified as important therapeutic targets that may help regulate inhibitory effects on TRPV1 and hence its desensitization and phosphorylation. Expand
Effect of ginger constituents and synthetic analogues on cyclooxygenase-2 enzyme in intact cells.
The SAR analysis of these phenolic compounds revealed three important structural features that affect COX-2 inhibition: lipophilicity of the alkyl side chain, and substitution pattern of hydroxy and carbonyl groups on the side chain. Expand
Activation of protein kinase C reverses capsaicin-induced calcium-dependent desensitization of TRPV1 ion channels.
Evidence is provided for a role of PKC in reversing capsaicin-induced calcium-dependent desensitization of TRPV1 ion channels and for a mutation of TRpV1 where phosphorylation sites serine502 and serine800 were replaced with alanine. Expand