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Ligand recognition and gating mechanism through three ligand-binding sites of human TRPM2 channel
TRPM2 is critically involved in diverse physiological processes including core temperature sensing, apoptosis, and immune response. TRPM2’s activation by Ca2+ and ADP ribose (ADPR), an… Expand
Monoclonal antibodies to the main immunogenic region of the nicotinic acetylcholine receptor bind to residues 61-76 of the alpha subunit.
- T. Barkas, J. Gabriel, +5 authors M. Ballivet
- Medicine, Biology
- The Journal of biological chemistry
- 25 April 1988
Monoclonal antibodies (mAbs) to the main immunogenic region (MIR) bind to fusion proteins containing region 37-200 of the alpha chain of Torpedo, mouse, and chicken nicotinic acetylcholine receptor.… Expand
Mapping the main immunogenic region and toxin-binding site of the nicotinic acetylcholine receptor.
- T. Barkas, A. Mauron, B. Roth, C. Alliod, S. Tzartos, M. Ballivet
- Biology, Medicine
- 2 January 1987
The alpha-chain of the nicotinic acetylcholine receptor carries the binding sites both for cholinergic ligands and for most experimentally induced or naturally occurring antibodies to the native… Expand
A modified nicotinic acetylcholine receptor lacking the ‘ion channel amphipathic helices’
- B. Roth, B. Schwendimann, G. Hughes, S. Tzartos, T. Barkas
- Chemistry, Medicine
- FEBS letters
- 31 August 1987
Antibodies to a synthetic peptide from the ‘amphipathic helix’ of the α‐chain of the nicotinic acetylcholine receptor (nAChR) bound both to detergent‐solubilised and membrane‐bound nAChR, indicating… Expand
Localization of the Main Immunogenic Region and Toxin Binding Site of the Nicotinic Acetylcholine Receptor a
We have used two approaches in order to map the main immunogenic region (MIR) and the a-bungarotoxin (aBTX) binding site of the nicotinic acetylcholine receptor (nAChR). Digestion of Torpedo nAChR by… Expand
Expression Cloning and Fusion Proteins as Tools to Study Receptor Structure
The nicotinic acetylcholine receptor (nAChR) is a complex molecule consisting of four different subunits α, β, γ and δ which form a pentameric structure containing two copies of the α-chain and one… Expand
Molecular dissection of the nicotinic acetylcholine receptor.
Ammonium sulphate precipitation overestimates titres of anti-peptide antisera.
Precipitation by 50% final saturation of ammonium sulphate, a method commonly used to estimate titres and affinity constants of antibodies, was found consistently to overestimate the titre of… Expand
Author response: Ligand recognition and gating mechanism through three ligand-binding sites of human TRPM2 channel
Ligand Recognition and Gating Mechanism of the TRPM2 Channel