• Publications
  • Influence
Estimation of population characteristics of pharmacokinetic parameters from routine clinical data
A general data analysis technique estimates average population values of pharmacokinetic parameters and their interindividual variability from clinical pharmacokinetic data gathered during theExpand
  • 407
  • 25
Modelling of individual pharmacokinetics for computer-aided drug dosage.
TLDR
A pharmacokinetic model and statistical methodology is presented which is designed to provide the basis for a clinically useful computer program to suggest optimal dosage regimens for a number of drugs for individual patients. Expand
  • 369
  • 14
Forecasting individual pharmacokinetics
Often drug dosage may be chosen rationally by use of plasma concentration (CP) as the “therapeutic” end point. The ability to accurately forecast the CP resulting from a dosage regimen is central toExpand
  • 423
  • 6
Improved computer-assisted digoxin therapy. A method using feedback of measured serum digoxin concentrations.
Automated feedback control methods were applied to a medical problem, in a computer program that used measured serum digoxin concentrations (as feedback) to predict future concentrations and toExpand
  • 96
  • 1
DifFerences in serum digoxin concentrations between outpatients and inpatients: An effect of compliance?
Concentrations of digoxin in serum were assayed at serial weekly visits (2 to 8) of outpatients receiving the drug (163 assays in 43 patients). A data analysis technique that models individualExpand
  • 46
  • 1
Instructional goals for physicians in the use of blood level data—and the contribution of computers
A knowledge of pharmacokinetics provides the potential for improving the physician's therapeutic decision‐making relating to such quantitative aspects of the drug regimen as the required individualExpand
  • 21
Computer-aided drug dosage
TLDR
Major efforts have been devoted to the application of computational techniques to medical diagnosis, a difficult computational task. Expand
  • 3
  • PDF
The statistical basis for forecasting individual pharmacokinetics
To accurately forecast, or predict the pharmacokinetics of a drug in an individual patient implies that one can accurately forecast the plasma drug concentration (PDC) time course that one will seeExpand
  • 1
Improved Computer-Assisted Digoxin Therapy
Abstract Automated feedback control methods were applied to a medical problem, in a computer program that used measured serum digoxin concentrations (as feedback) to predict future concentrations a...
Computer-aided drug dosage