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Inhibition of Cell Division in Escherichia coli by Electrolysis Products from a Platinum Electrode
In E. coli, the presence of certain group VIIIb transition metal compounds in concentrations of about 1–10 parts per million of the metal in the culture medium causes an inhibition of the cell division process, which implies that the growth process is not markedly affected. Expand
Platinum Compounds: a New Class of Potent Antitumour Agents
The platinum compounds inhibit sarcoma 180 and leukaemia L1210 in mice and reversibly inhibit cell division in Gram-negative rods1–4. Expand
Fundamental studies with cisplatin.
Platinum Complexes for the Treatment of Cancer
AbstractSome platinum coordination complexes are active anticancer drugs in animal and man. This new class of chemotherapeutics was discovered during the course of investigation of the electric fieldExpand
Platinum coordination complexes in cancer chemotherapy
  • B. Rosenberg
  • Chemistry, Medicine
  • Naturwissenschaften
  • 1 September 1973
C cis-Dichlorodiammineplatinum (II), the most widely investigated drug, has completed Phase I clinical trials and is now in Phase II, and appears to be a broad spectrum anti-tumor drug. Expand
Anticancer activity of cis-dichlorodiammineplatinum(II) and some relevant chemistry.
  • B. Rosenberg
  • Chemistry, Medicine
  • Cancer treatment reports
  • 1 September 1979
The detection of trace amounts of trans-Pt(NH3)2Cl2 in the presence of cis-Pt(NH3)2Cl2. A high performance liquid chromatographic application of kurnakow's test
Abstract Treatment of mixtures of cis and trans Pt(NH3)2Cl2 with thiourea (thu) gave Pt(thu)4Cl2 and trans [Pt(NH3)2(thu)2]Cl2 which were separated and quantified by high-performance liquidExpand
The nature of the charge carriers in solvated biomacromolecules
Solid state electrolysis experiments were performed on the biomolecules, hemoglobin, cytochromec, collagen, lecithin and melanin at various hydration states; and for hemoglobin at various solvationExpand
Platinum-induced filamentous growth in Escherichia coli.
Certain group VIIIB transition metal compounds were found to inhibit cell division in Escherichia coli, causing marked filamentous growth. Gram-negative bacilli were the most sensitive to thisExpand