• Publications
  • Influence
Coxsackie B4 virus infection of beta cells and natural killer cell insulitis in recent-onset type 1 diabetic patients.
Type 1 diabetes is characterized by T cell-mediated autoimmune destruction of pancreatic beta cells. Several studies have suggested an association between Coxsackie enterovirus seroconversion andExpand
Induction of Treg by monocyte‐derived DC modulated by vitamin D3 or dexamethasone: Differential role for PD‐L1
Specific therapy with modulated DC may restore immunological tolerance, thereby obviating the need for chronic immunosuppression in transplantation or autoimmunity. In this study we compared theExpand
Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health.
According to the quality of response they mediate, autoreactive T cells recognizing islet beta cell peptides could represent both disease effectors in the development of type 1 diabetes (T1DM) andExpand
Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes.
Type 1 diabetes is a T-cell-mediated disease that is associated with loss of immunological tolerance to self-antigens. The mechanisms involved in maintenance of peripheral tolerance include aExpand
Coxsackie B4 virus infection of β cells and natural killer cell insulitis in recent-onset type 1 diabetic patients
Type 1 diabetes is characterized by T cell-mediated autoimmune destruction of pancreatic β cells. Several studies have suggested an association between Coxsackie enterovirus seroconversion and onsetExpand
CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope.
The final pathway of beta cell destruction leading to insulin deficiency, hyperglycemia, and clinical type 1 diabetes is unknown. Here we show that circulating CTLs can kill beta cells viaExpand
Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients
In situ tetramer staining reveals the presence of islet antigen-reactive CD8+ T cells in pancreatic islets from deceased type 1 diabetes patients.
Mannose-binding lectin: clinical implications for infection, transplantation, and autoimmunity.
Mannose-binding lectin (MBL) is a recognition molecule of the lectin pathway of complement and a key component of innate immunity. MBL variant alleles have been described in the coding region of theExpand
Islet inflammation and CXCL10 in recent‐onset type 1 diabetes
Type 1 diabetes results from a T cell‐mediated destruction of insulin‐producing pancreatic β cells. Little is known on local factors contributing to migration of T cells to pancreatic tissue. WeExpand
Antigen targets of type 1 diabetes autoimmunity.
  • B. Roep, M. Peakman
  • Biology, Medicine
  • Cold Spring Harbor perspectives in medicine
  • 1 April 2012
Type 1 diabetes is characterized by recognition of one or more β-cell proteins by the immune system. The list of target antigens in this disease is ever increasing and it is conceivable thatExpand
...
1
2
3
4
5
...