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Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease?
Hyperuricemia is associated with hypertension, vascular disease, renal disease, and cardiovascular events. In this report, we review the epidemiologic evidence and potential mechanisms for thisExpand
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Uric Acid Induces Hepatic Steatosis by Generation of Mitochondrial Oxidative Stress
Background: Uric acid is an independent risk factor in fructose-induced fatty liver, but whether it is a marker or a cause remains unknown. Results: Hepatocytes exposed to uric acid developedExpand
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Oxidative stress, renal infiltration of immune cells, and salt-sensitive hypertension: all for one and one for all.
Recent evidence indicates that interstitial infiltration of T cells and macrophages plays a role in the pathogenesis of salt-sensitive hypertension. The present review examines this evidence andExpand
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The current state of poststreptococcal glomerulonephritis.
Poststreptococcal glomerulonephritis is one of the oldest recognized renal diseases. In the past three decades, significant changes have occurred in its epidemiology, in new insight gained in theExpand
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Mild hyperuricemia induces vasoconstriction and maintains glomerular hypertension in normal and remnant kidney rats.
BACKGROUND Hyperuricemia has been associated with renal disease. Because glomerular hemodynamic alterations critically contribute to initiation and progression of renal disease, we evaluated theExpand
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Reduction of renal immune cell infiltration results in blood pressure control in genetically hypertensive rats.
Immunocompetent cells infiltrate the kidney in several models of experimental hypertension. We have previously shown that reduction of this infiltrate results in prevention of salt-sensitiveExpand
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The role of uric acid in the pathogenesis of human cardiovascular disease
Hyperuricaemia is common in subjects with cardiovascular disease, but is not commonly considered a true risk factor. Recent studies suggest that uric acid is biologically active and can stimulateExpand
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Opposing effects of fructokinase C and A isoforms on fructose-induced metabolic syndrome in mice
Fructose intake from added sugars correlates with the epidemic rise in obesity, metabolic syndrome, and nonalcoholic fatty liver disease. Fructose intake also causes features of metabolic syndrome inExpand
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Mycophenolate mofetil prevents salt-sensitive hypertension resulting from angiotensin II exposure.
BACKGROUND Interstitial mononuclear cell infiltration is a feature of experimental models of salt-sensitive hypertension (SSHTN). Since several products of these cells are capable of modifying localExpand
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Uric Acid Stimulates Fructokinase and Accelerates Fructose Metabolism in the Development of Fatty Liver
Excessive dietary fructose intake may have an important role in the current epidemics of fatty liver, obesity and diabetes as its intake parallels the development of these syndromes and because itExpand
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