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The Connecdenn DENN domain: a GEF for Rab35 mediating cargo-specific exit from early endosomes.
The DENN domain is an evolutionarily ancient protein module. Mutations in the DENN domain cause developmental defects in plants and human diseases, yet the function of this common module is unknown.Expand
Tandem MS analysis of brain clathrin-coated vesicles reveals their critical involvement in synaptic vesicle recycling.
Tandem MS has identified 209 proteins of clathrin-coated vesicles (CCVs) isolated from rat brain. An overwhelming abundance of peptides were assigned to the clathrin coat with a 1:1 stoichiometryExpand
Interplay between Rab35 and Arf6 controls cargo recycling to coordinate cell adhesion and migration
Summary Cells inversely adjust the plasma membrane levels of integrins and cadherins during cell migration and cell–cell adhesion but the regulatory mechanisms that coordinate these traffickingExpand
A dynamin 1-, dynamin 3- and clathrin-independent pathway of synaptic vesicle recycling mediated by bulk endocytosis
The exocytosis of synaptic vesicles (SVs) elicited by potent stimulation is rapidly compensated by bulk endocytosis of SV membranes leading to large endocytic vacuoles (‘bulk’ endosomes).Expand
All three PACSIN isoforms bind to endocytic proteins and inhibit endocytosis.
The PACSINs are a family of cytoplasmic phosphoproteins that play a role in vesicle formation and transport. We report the cloning and cDNA sequencing of PACSIN 3 and the analysis of all three PACSINExpand
Two WXXF‐based motifs in NECAPs define the specificity of accessory protein binding to AP‐1 and AP‐2
The adaptor proteins AP‐2 and AP‐1/GGAs are essential components of clathrin coats at the plasma membrane and trans‐Golgi network, respectively. The adaptors recruit accessory proteins toExpand
The p75NTR intracellular domain generated by neurotrophin-induced receptor cleavage potentiates Trk signaling
The p75 neurotrophin receptor (p75NTR) potentiates Trk signaling, but the underlying mechanisms remain uncertain. Here, we examine the relationship between p75NTR cleavage and Trk signaling. We foundExpand
Identification of a family of endocytic proteins that define a new α‐adaptin ear‐binding motif
Endocytosis by clathrin‐coated vesicles (CCVs) is an important mechanism mediating protein internalization. Here, we show that two proteins identified through a proteomics analysis of CCVs are newExpand
Identification of a family of endocytic proteins that define a new alpha-adaptin ear-binding motif.
Endocytosis by clathrin-coated vesicles (CCVs) is an important mechanism mediating protein internalization. Here, we show that two proteins identified through a proteomics analysis of CCVs are newExpand
NECAP 1 Regulates AP-2 Interactions to Control Vesicle Size, Number, and Cargo During Clathrin-Mediated Endocytosis
The endocytic protein NECAP 1 cooperates with the endocytic adapter protein AP-2 to modulate interactions with accessory proteins and clathrin and to control the size, number, and cargo content ofExpand
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