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Muscarinic activity and receptor binding of the enantiomers of aceclidine and its methiodide.

• B. Ringdahl, F J Ehler, Donald J. Jenden
• Molecular pharmacology
• 1982

The agents (+)- and (-)-aceclidine (3-acetoxyquinuclidine), (+)- and (-)-N-methylaceclidine, and oxotremorine were compared in their ability to inhibit specific 3H-labeled (+/-)-3-quinuclidinyl… (More)

Acetylene compounds of potential pharmacological value. XXVIII. Oxotremorine analogues substituted with a methyl group in the lactam ring.

• B. Ringdahl, Z Muhi-Eldeen, Christina Ljunggren, Bo Karlén, Bahram Resul, R. Dahlbom
• Acta pharmaceutica Suecica
• 1979

Muscarinic activity in the isolated guinea pig ileum of some carboxamides related to oxotremorine.

• B. Ringdahl, Bahram Resul, Donald J. Jenden, R. Dahlbom
• European journal of pharmacology
• 1982

A series of structural analogues of the potent oxotremorine-like agent N-(4-pyrrolidino-2-butynyl)-N-methyl-acetamide (1) was investigated for muscarinic activity in the isolated guinea pig ileum.… (More)

The conversion of 2-chloroalkylamine analogues of oxotremorine to aziridinium ions and their interactions with muscarinic receptors in the guinea pig ileum.

• B. Ringdahl, Bahram Resul, Frederick J. Ehlert, Donald J. Jenden, R. Dahlbom
• Molecular pharmacology
• 1984

Two mustard analogues of oxotremorine, N-[4-(2-chloroethylmethylamino)-2-butynyl]-2-pyrrolidone (BM 123) and N-[4-(2-chloromethylpyrrolidino)-2-butynyl]-2-pyrrolidone (BM 130), were synthesized. BM… (More)

Structural requirements for muscarinic receptor occupation and receptor activation by oxotremorine analogs in the guinea-pig ileum.

• B. Ringdahl
• The Journal of pharmacology and experimental…
• 1985

The muscarinic activities in the isolated guinea-pig ileum of nine analogs of oxotremorine, modified only in the amino group, were resolved into affinity and efficacy components. The method used… (More)

Tertiary 2-haloethylamine derivatives of the muscarinic agent McN-A-343, [4-[[N-(3-chlorophenyl)carbamoyl]oxy]-2-butynyl]trimethylammonium chloride.

• B. Ringdahl, C Mellin, Frederick J. Ehlert, Margareth Roch, Kevin M. Rice, Donald J. Jenden
• Journal of medicinal chemistry
• 1990

4-[(2-Chloroethyl)methylamino]-2-butynyl N-(3-chlorophenyl)carbamate (2) and 4-[(2-bromoethyl)methylamino]-2-butynyl N-(3-chlorophenyl)carbamate (3) were synthesized. Compounds 2 and 3 cyclized at… (More)

Centrally active antimuscarinic analogs of oxotremorine selectively block physostigmine-induced hypertension, but not peripheral muscarinic vasodepression.

• Hugo M. Vargas, B. Ringdahl
• The Journal of pharmacology and experimental…
• 1990

Some tertiary antimuscarinic amines related to oxotremorine were compared with atropine and scopolamine for their ability to block physostigmine-induced hypertension and acetylcholine-induced… (More)

Dissociation constants and relative efficacies of acetylcholine, (+)- and (-)-methacholine at muscarinic receptors in the guinea-pig ileum.

• B. Ringdahl
• British journal of pharmacology
• 1986

Dissociation constants (KA) and relative efficacies of acetylcholine, (+)-methacholine and (-)-methacholine at muscarinic receptors in the guinea-pig isolated ileum were determined in the absence and… (More)

Tertiary 3- and 4-haloalkylamine analogues of oxotremorine as prodrugs of potent muscarinic agonists.

• B. Ringdahl, Margareth Roch, Donald J. Jenden
• Journal of medicinal chemistry
• 1988

A series of tertiary 3- and 4-haloalkylamines related to the muscarinic agent oxotremorine was synthesized. The compounds cyclized in neutral aqueous solution to quaternary ammonium salts, which, in… (More)

Inhibition of high affinity choline transport by stereoisomers of some 3-quinuclidinol derivatives.

• B. Ringdahl, Richard Scott Jope, Donald J. Jenden
• Biochemical pharmacology
• 1984

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