B. Ringdahl

Publications92
h-index14
Citations764
Highly Influential Citations11
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Pharmacological properties of oxotremorine and its analogs.
The mechanism of action of oxotremorine is reviewed. A number of analogs of oxotremorine, including agonists, partial agonists and antagonists, are described. Many of these are potent and highly… Expand
  • 59
  • 1
Structural requirements for muscarinic receptor occupation and receptor activation by oxotremorine analogs in the guinea-pig ileum.
  • B. Ringdahl
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental…
  • 1985
The muscarinic activities in the isolated guinea-pig ileum of nine analogs of oxotremorine, modified only in the amino group, were resolved into affinity and efficacy components. The method used… Expand
  • 18
  • 1
Regional differences in receptor reserve for analogs of oxotremorine in vivo: implications for development of selective muscarinic agonists.
The muscarinic actions of several analogs of oxotremorine were compared in the mouse. Compounds such as AKS 19 and BM 5 having low intrinsic efficacy (partial agonists) differentiated between… Expand
  • 21
  • 1
Dissociation constants and relative efficacies of acetylcholine, (+)‐ and (‐)‐methacholine at muscarinic receptors in the guinea‐pig ileum
  • B. Ringdahl
  • Chemistry, Medicine
  • British journal of pharmacology
  • 1 September 1986
1 Dissociation constants (KA) and relative efficacies of acetylcholine, (+)‐methacholine and (‐)‐methacholine at muscarinic receptors in the guinea‐pig isolated ileum were determined in the absence… Expand
  • 10
  • 1
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The conversion of 2-chloroalkylamine analogues of oxotremorine to aziridinium ions and their interactions with muscarinic receptors in the guinea pig ileum.
Two mustard analogues of oxotremorine, N-[4-(2-chloroethylmethylamino)-2-butynyl]-2-pyrrolidone (BM 123) and N-[4-(2-chloromethylpyrrolidino)-2-butynyl]-2-pyrrolidone (BM 130), were synthesized. BM… Expand
  • 20
  • 1
Muscarinic activity and receptor binding of the enantiomers of aceclidine and its methiodide.
The agents (+)- and (-)-aceclidine (3-acetoxyquinuclidine), (+)- and (-)-N-methylaceclidine, and oxotremorine were compared in their ability to inhibit specific 3H-labeled (+/-)-3-quinuclidinyl… Expand
  • 19
  • 1
Circular Dichroism of Aporphines
  • 37
  • 1
Muscarinic activity in the isolated guinea pig ileum of some carboxamides related to oxotremorine.
A series of structural analogues of the potent oxotremorine-like agent N-(4-pyrrolidino-2-butynyl)-N-methyl-acetamide (1) was investigated for muscarinic activity in the isolated guinea pig ileum.… Expand
  • 7
  • 1
Acetylene compounds of potential pharmacological value. XXVIII. Oxotremorine analogues substituted with a methyl group in the lactam ring.
  • 9
  • 1
5-Methyl-2-pyrrolidone analogues of oxotremorine as selective muscarinic agonists.
  • B. Ringdahl
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 1 March 1988
A series of N-(4-amino-2-butynyl)-5-methyl-2-pyrrolidones modified only in the amino group was synthesized. The compounds were agonists, partial agonists, and antagonists on the isolated guinea pig… Expand
  • 10
  • 1