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- Publications
- Influence
Pharmacological properties of oxotremorine and its analogs.
- B. Ringdahl, D. Jenden
- Chemistry, Medicine
- Life sciences
- 23 May 1983
The mechanism of action of oxotremorine is reviewed. A number of analogs of oxotremorine, including agonists, partial agonists and antagonists, are described. Many of these are potent and highly… Expand
Structural requirements for muscarinic receptor occupation and receptor activation by oxotremorine analogs in the guinea-pig ileum.
- B. Ringdahl
- Chemistry, Medicine
- The Journal of pharmacology and experimental…
- 1985
The muscarinic activities in the isolated guinea-pig ileum of nine analogs of oxotremorine, modified only in the amino group, were resolved into affinity and efficacy components. The method used… Expand
Regional differences in receptor reserve for analogs of oxotremorine in vivo: implications for development of selective muscarinic agonists.
- B. Ringdahl, M. Roch, D. Jenden
- Chemistry, Medicine
- The Journal of pharmacology and experimental…
- 1 August 1987
The muscarinic actions of several analogs of oxotremorine were compared in the mouse. Compounds such as AKS 19 and BM 5 having low intrinsic efficacy (partial agonists) differentiated between… Expand
Dissociation constants and relative efficacies of acetylcholine, (+)‐ and (‐)‐methacholine at muscarinic receptors in the guinea‐pig ileum
- B. Ringdahl
- Chemistry, Medicine
- British journal of pharmacology
- 1 September 1986
1 Dissociation constants (KA) and relative efficacies of acetylcholine, (+)‐methacholine and (‐)‐methacholine at muscarinic receptors in the guinea‐pig isolated ileum were determined in the absence… Expand
The conversion of 2-chloroalkylamine analogues of oxotremorine to aziridinium ions and their interactions with muscarinic receptors in the guinea pig ileum.
- B. Ringdahl, B. Resul, F. Ehlert, D. Jenden, R. Dahlbom
- Chemistry, Medicine
- Molecular pharmacology
- 1 September 1984
Two mustard analogues of oxotremorine, N-[4-(2-chloroethylmethylamino)-2-butynyl]-2-pyrrolidone (BM 123) and N-[4-(2-chloromethylpyrrolidino)-2-butynyl]-2-pyrrolidone (BM 130), were synthesized. BM… Expand
Muscarinic activity and receptor binding of the enantiomers of aceclidine and its methiodide.
- B. Ringdahl, F. J. Ehler, D. Jenden
- Chemistry, Medicine
- Molecular pharmacology
- 1 May 1982
The agents (+)- and (-)-aceclidine (3-acetoxyquinuclidine), (+)- and (-)-N-methylaceclidine, and oxotremorine were compared in their ability to inhibit specific 3H-labeled (+/-)-3-quinuclidinyl… Expand
Muscarinic activity in the isolated guinea pig ileum of some carboxamides related to oxotremorine.
- B. Ringdahl, B. Resul, D. Jenden, R. Dahlbom
- Chemistry, Medicine
- European journal of pharmacology
- 5 November 1982
A series of structural analogues of the potent oxotremorine-like agent N-(4-pyrrolidino-2-butynyl)-N-methyl-acetamide (1) was investigated for muscarinic activity in the isolated guinea pig ileum.… Expand
Acetylene compounds of potential pharmacological value. XXVIII. Oxotremorine analogues substituted with a methyl group in the lactam ring.
- B. Ringdahl, Z. Muhi-Eldeen, C. Ljunggren, B. Karlén, B. Resul, R. Dahlbom
- Chemistry, Medicine
- Acta pharmaceutica Suecica
- 1979
5-Methyl-2-pyrrolidone analogues of oxotremorine as selective muscarinic agonists.
- B. Ringdahl
- Chemistry, Medicine
- Journal of medicinal chemistry
- 1 March 1988
A series of N-(4-amino-2-butynyl)-5-methyl-2-pyrrolidones modified only in the amino group was synthesized. The compounds were agonists, partial agonists, and antagonists on the isolated guinea pig… Expand