• Publications
  • Influence
Shear-induced tyrosine phosphorylation in endothelial cells requires Rac1-dependent production of ROS.
The shear-induced intracellular signal transduction pathway in vascular endothelial cells involves tyrosine phosphorylation and activation of mitogen-activated protein (MAP) kinase, which may beExpand
  • 148
  • 4
Local hemodynamics affect monocytic cell adhesion to a three-dimensional flow model coated with E-selectin.
Monocyte adhesion to the endothelium depends on concentrations of receptors/ligands, local concentrations of chemoattractants, monocyte transport to the endothelial surface and hemodynamic forces.Expand
  • 59
  • 4
Mitochondrial Dynamics and Motility Inside Living Vascular Endothelial Cells: Role of Bioenergetics
The mitochondrial network is dynamic with conformations that vary between a tubular continuum and a fragmented state. The equilibrium between mitochondrial fusion/fission, as well as the organelleExpand
  • 49
  • 3
  • PDF
Fluid Mechanical Forces and Endothelial Mitochondria: A Bioengineering Perspective
Endothelial cell dysfunction is the hallmark of every cardiovascular disease/condition, including atherosclerosis and ischemia/reperfusion injury. Fluid shear stress acting on the vascularExpand
  • 21
  • 3
An experimental and theoretical study on the dissolution of mural fibrin clots by tissue-type plasminogen activator.
During thrombolytic therapy and after recanalization is achieved, reduction in the volume of mural thrombi is desirable. Mural thrombi are known to contribute to rethrombosis and reocclusion. TheExpand
  • 27
  • 2
Adhesion of flowing monocytes to hypoxia-reoxygenation-exposed endothelial cells: role of Rac1, ROS, and VCAM-1.
Production of reactive oxygen species (ROS) by ischemic tissue after ischemia-reperfusion (I/RP) is an important factor that contributes to tissue injury. The small GTPase Rac1 mediates the oxidativeExpand
  • 43
  • 2
  • PDF
Shear stress augments the enhanced adhesive phenotype of cells expressing the Pro33 isoform of integrin β3
Adhesion of platelets to the exposed extracellular matrix proteins at sites of vascular injury is partly regulated by the local fluid shear stress. Because the Leu33Pro (PlA) polymorphism of integrinExpand
  • 26
  • 2
Mitochondrial fission in endothelial cells after simulated ischemia/reperfusion: role of nitric oxide and reactive oxygen species.
Ischemia (I)/reperfusion (RP)-induced endothelial cell (EC) injury is thought to be due to mitochondrial reactive oxygen species (mtROS) production. MtROS have been implicated in mitochondrialExpand
  • 80
  • 1
Shear-induced reactive nitrogen species inhibit mitochondrial respiratory complex activities in cultured vascular endothelial cells.
There is evidence that nitric oxide (NO), superoxide (O(2)(*-)), and their associated reactive nitrogen species (RNS) produced by vascular endothelial cells (ECs) in response to hemodynamic forcesExpand
  • 46
  • 1
  • PDF
Mitochondria-Derived Reactive Oxygen Species Mediate Heme Oxygenase-1 Expression in Sheared Endothelial Cells
Bovine aortic endothelial cells (ECs) respond to nitric oxide (NO) donors by activating the redox-sensitive NF-E2-related factor 2/antioxidant response element pathway and up-regulating hemeExpand
  • 65
  • 1