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Molecular dissection of the photoreceptor ribbon synapse
The ribbon complex of retinal photoreceptor synapses represents a specialization of the cytomatrix at the active zone (CAZ) present at conventional synapses. In mice deficient for the CAZ proteinExpand
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Mammalian Abp1, a Signal-Responsive F-Actin–Binding Protein, Links the Actin Cytoskeleton to Endocytosis via the Gtpase Dynamin
The actin cytoskeleton has been implicated in endocytosis, yet few molecular links to the endocytic machinery have been established. Here we show that the mammalian F-actin–binding protein Abp1Expand
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Cordon-Bleu Is an Actin Nucleation Factor and Controls Neuronal Morphology
Despite the wealth of different actin structures formed, only two actin nucleation factors are well established in vertebrates: the Arp2/3 complex and formins. Here, we describe a further nucleator,Expand
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Syndapin I, a synaptic dynamin-binding protein that associates with the neural Wiskott-Aldrich syndrome protein.
The GTPase dynamin has been clearly implicated in clathrin-mediated endocytosis of synaptic vesicle membranes at the presynaptic nerve terminal. Here we describe a novel 52-kDa protein in rat brainExpand
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Syndapin Isoforms Participate in Receptor-Mediated Endocytosis and Actin Organization
Syndapin I (SdpI) interacts with proteins involved in endocytosis and actin dynamics and was therefore proposed to be a molecular link between the machineries for synaptic vesicle recycling andExpand
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SH3-domain-containing proteins function at distinct steps in clathrin-coated vesicle formation
Several SH3-domain-containing proteins have been implicated in endocytosis by virtue of their interactions with dynamin; however, their functions remain undefined. Here we report the efficientExpand
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Molecular Links between Endocytosis and the Actin Cytoskeleton
The endocytosis process is of critical importance for a variety of cellular life functions. Vesicle formation during receptor-mediated endocytosis involves a complex protein machinery and additionalExpand
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Let's go bananas: revisiting the endocytic BAR code
Against the odds of membrane resistance, members of the BIN/Amphiphysin/Rvs (BAR) domain superfamily shape membranes and their activity is indispensable for a plethora of life functions. WhileExpand
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The syndapin protein family: linking membrane trafficking with the cytoskeleton
Syndapins – also called PACSINs – are highly conserved Src-homology 3 (SH3)-domain-containing proteins that seem to exist in all multicellular eukaryotes. They interact with the large GTPase dynaminExpand
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EHD proteins associate with syndapin I and II and such interactions play a crucial role in endosomal recycling.
EHD proteins were shown to function in the exit of receptors and other membrane proteins from the endosomal recycling compartment. Here, we identify syndapins, accessory proteins in vesicle formationExpand
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