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Natural history of experimental arterial chronic total occlusions.
OBJECTIVES We sought to perform the first systematic study of the natural history of chronic total arterial occlusions (CTOs) in an experimental model. BACKGROUND Angioplasty of CTOs has lowExpand
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Quantitative tracking of edema, hemorrhage, and microvascular obstruction in subacute myocardial infarction in a porcine model by MRI
Pathophysiological responses after acute myocardial infarction include edema, hemorrhage, and microvascular obstruction along with cellular damage. The in vivo evolution of these processesExpand
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Human Embryonic Stem Cell-Derived Cardiomyocytes Regenerate the Infarcted Pig Heart but Induce Ventricular Tachyarrhythmias
Summary Human embryonic stem cell-derived cardiomyocytes (hESC-CMs) show considerable promise for regenerating injured hearts, and we therefore tested their capacity to stably engraft in aExpand
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Microvessels in chronic total occlusions: pathways for successful guidewire crossing?
Arterial chronic total occlusions (CTO) are a common and clinically relevant problem in patients with coronary artery disease. Percutaneous coronary intervention (PCI) success rates in a wide rangeExpand
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Proteins mediating collagen biosynthesis and accumulation in arterial repair: novel targets for anti-restenosis therapy.
Events contributing to restenosis after coronary interventions include platelet aggregation, inflammatory cell infiltration, growth factor release, and accumulation of smooth muscle cells (SMCs) andExpand
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Intravascular and extravascular microvessel formation in chronic total occlusions a micro-CT imaging study.
OBJECTIVES The purpose of this study was to characterize the 3-dimensional structure of intravascular and extravascular microvessels during chronic total occlusion (CTO) maturation in a rabbit model.Expand
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Myocardial BOLD imaging at 3 T using quantitative T2: Application in a myocardial infarct model
Left ventricular remodeling as a result of acute myocardial infarction (AMI) is associated with significant morbidity, leading to cardiovascular dysfunction, disability, and death. Despite successfulExpand
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Collagenase Plaque Digestion for Facilitating Guide Wire Crossing in Chronic Total Occlusions
Background—Chronic total occlusions (CTOs) are associated with significant angina, impaired left ventricular function, and worse long-term outcomes. Percutaneous coronary interventions in CTO areExpand
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Expansive remodeling in venous bypass grafts: novel implications for vein graft disease.
OBJECTIVE To date, intimal hyperplasia has been regarded as the principle mechanism responsible for subsequent vein graft disease. Lumen remodeling has not been previously considered as an additionalExpand
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Adventitial microvessel formation after coronary stenting and the effects of SU11218, a tyrosine kinase inhibitor.
OBJECTIVES The aim of this study was to delineate the temporal profile of adventitial microvessel (Ad-MV) formation after stenting, its relationship to arterial wall hypoxia, and the effects of aExpand
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