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A Three-Dimensional Organoid Culture System Derived from Human Glioblastomas Recapitulates the Hypoxic Gradients and Cancer Stem Cell Heterogeneity of Tumors Found In Vivo.
- Christopher G. Hubert, Maricruz Rivera, +7 authors J. Rich
- Biology, Medicine
- Cancer research
- 15 April 2016
Many cancers feature cellular hierarchies that are driven by tumor-initiating cancer stem cells (CSC) and rely on complex interactions with the tumor microenvironment. Standard cell culture… Expand
Cancer Stem Cells: The Architects of the Tumor Ecosystem.
Cancer stem cells (CSCs) proactively remodel their microenvironment to maintain a supportive niche. Viewed through the lens of an ecosystem, numerous tumor components have multi-directional… Expand
Sphingosine 1-phosphate signaling at the blood-brain barrier.
The characterization of molecular pathways that modulate blood-brain barrier (BBB) function and integrity has been fueled by a growing body of literature implicating BBB dysfunction in a wide range… Expand
Nicotinamide metabolism regulates glioblastoma stem cell maintenance.
Metabolic dysregulation promotes cancer growth through not only energy production, but also epigenetic reprogramming. Here, we report that a critical node in methyl donor metabolism, nicotinamide… Expand
Targeting Glioma Stem Cells through Combined BMI1 and EZH2 Inhibition
Glioblastomas are lethal cancers defined by angiogenesis and pseudopalisading necrosis. Here, we demonstrate that these histological features are associated with distinct transcriptional programs,… Expand
Purine synthesis promotes maintenance of brain tumor initiating cells in glioma
Brain tumor initiating cells (BTICs), also known as cancer stem cells, hijack high-affinity glucose uptake active normally in neurons to maintain energy demands. Here we link metabolic dysregulation… Expand
MYC-Regulated Mevalonate Metabolism Maintains Brain Tumor-Initiating Cells.
Metabolic dysregulation drives tumor initiation in a subset of glioblastomas harboring isocitrate dehydrogenase (IDH) mutations, but metabolic alterations in glioblastomas with wild-type IDH are… Expand
Targeting Glioblastoma Stem Cells through Disruption of the Circadian Clock.
Glioblastomas are highly lethal cancers, containing self-renewing glioblastoma stem cells (GSCs). Here, we show that GSCs, differentiated glioblastoma cells (DGCs), and non-malignant brain cultures… Expand
Therapeutic Targeting of Ependymoma as Informed by Oncogenic Enhancer Profiling
Genomic sequencing has driven precision-based oncology therapy; however, the genetic drivers of many malignancies remain unknown or non-targetable, so alternative approaches to the identification of… Expand
Reciprocal Signaling between Glioblastoma Stem Cells and Differentiated Tumor Cells Promotes Malignant Progression.
Glioblastoma is the most lethal primary brain tumor; however, the crosstalk between glioblastoma stem cells (GSCs) and their supportive niche is not well understood. Here, we interrogated reciprocal… Expand