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Melatonin: Nature's most versatile biological signal?
TLDR
Melatonin is principally secreted at night and is centrally involved in sleep regulation, as well as in a number of other cyclical bodily activities, and its sleep-facilitating properties have been found to be useful for treating insomnia symptoms in elderly and depressive patients. Expand
A review of the evidence supporting melatonin's role as an antioxidant
TLDR
Melatonin is remarkably potent in protecting against free radical damage induced by a variety of means, and DNA damage resulting from either the exposure of animals to the chemical carcinogen safrole or to ionizing radiation is markedly reduced when melatonin is co‐administered. Expand
Circadian Rhythms, Oxidative Stress, and Antioxidative Defense Mechanisms
TLDR
A general effect of oxidative stress may consist in declines of easily oxidizable signaling molecules such as melatonin, and this can have consequences on the circadian intraorganismal organization and expression of overt rhythms. Expand
Effect of tryptophan administration on circulating melatonin levels in chicks and rats: evidence for stimulation of melatonin synthesis and release in the gastrointestinal tract.
TLDR
The possibility is discussed that the sedating, sleep inducing effects of Trp are mediated by the Trp-induced elevation of circulating melatonin. Expand
Melatonin stimulates brain glutathione peroxidase activity
TLDR
Brain glutathione peroxidase activity is higher at night than during the day and is correlated with high night-time tissue melatonin levels, which might be an important mechanism by which melatonin exerts its potent neuroprotective effects. Expand
Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease
TLDR
Administration of melatonin partially inhibited the expected time‐dependent elevation of β‐amyloid, reduced abnormal nitration of proteins, and increased survival in the treated transgenic mice, and these findings may bear relevance to the pathogenesis and therapy of AD. Expand
Melatonin, hydroxyl radical‐mediated oxidative damage, and aging: A hypothesis
TLDR
Experiments investigating the effects of endogenous excitatory amino acid antagonists and stimulants of melatonin biosynthesis such as magnesium may finally lead to novel therapeutic approaches for the prevention of degeneration and dysdifferentiation associated with diseases related to premature aging. Expand
Pathophysiology of depression: Role of sleep and the melatonergic system
TLDR
The novel antidepressant agomelatine, which combines the properties of a 5-HT(2C) antagonist and a melatonergic MT(1)/MT(2) receptor agonist, has been found very effective for resetting the disturbed sleep/wake cycle and in improving the clinical status of MDD. Expand
Evaluation of the antioxidant activity of melatonin in vitro.
TLDR
The data show that melatonin exerts only limited direct antioxidant activities and serotonin was weakly pro-oxidant in the ferric-bleomycin system and strongly pro-Oxidants in the Fe(3+)-EDTA/H2O-deoxyribose system. Expand
On the primary functions of melatonin in evolution: Mediation of photoperiodic signals in a unicell, photooxidation, and scavenging of free radicals *
TLDR
It is observed that cyst forma‐tion can be induced by various monoamine oxidase inhibitors and protonophores, that 5MT dramatically stimulates H‐dependent bioluminescence and leads to a decrease of cytoplasmic pH, as shown by measurements of dicyanohydroquinone fluorescence. Expand
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