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Formation of the vulva in Caenorhabditis elegans: a paradigm for organogenesis.
The genes involved in the inductive interactions that specify cell fates in the vulva of Caenorhabditis elegans are known in some detail. However, little is known about the morphogenesis of thisExpand
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Cell fusions in the developing epithelial of C. elegans.
In this paper we characterize the order of hypodermal cell fusions in the Caenorhabditis elegans hermaphrodite. Somatic cell fusions are part of the developmental program of many tissues in a varietyExpand
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The LIM domain protein UNC-95 is required for the assembly of muscle attachment structures and is regulated by the RING finger protein RNF-5 in C. elegans
Here, we describe a new muscle LIM domain protein, UNC-95, and identify it as a novel target for the RING finger protein RNF-5 in the Caenorhabditis elegans body wall muscle. unc-95(su33) animalsExpand
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The type I membrane protein EFF-1 is essential for developmental cell fusion.
Multinucleate cells are widespread in nature, yet the mechanism by which cells fuse their plasma membranes is poorly understood. To identify animal fusogens, we performed new screens for mutationsExpand
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Trends, Stasis, and Drift in the Evolution of Nematode Vulva Development
BACKGROUND A surprising amount of developmental variation has been observed for otherwise highly conserved features, a phenomenon known as developmental system drift. Either stochastic processesExpand
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Virus and cell fusion mechanisms.
  • B. Podbilewicz
  • Medicine, Biology
  • Annual review of cell and developmental biology
  • 6 October 2014
In biomembrane fusion pathways, membranes are destabilized through insertions of amphipathic protein segments, lipid reorganization via hemifusion, protein restructuring, and dimpling of theExpand
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The small ubiquitin-like modifier (SUMO) is required for gonadal and uterine-vulval morphogenesis in Caenorhabditis elegans.
The small ubiquitin-like modifier (SUMO) modification alters the subcellular distribution and function of its substrates. Here we show the major role of SUMO during the development of theExpand
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Genetic basis of cell-cell fusion mechanisms.
Cell-cell fusion in sexually reproducing organisms is a mechanism to merge gamete genomes and, in multicellular organisms, it is a strategy to sculpt organs, such as muscle, bone, and placenta.Expand
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LIN-39/Hox triggers cell division and represses EFF-1/fusogen-dependent vulval cell fusion.
General mechanisms by which Hox genes establish cell fates are known. However, a few Hox effectors mediating cell behaviors have been identified. Here we found the first effector of LIN-39/HoxD4/DfdExpand
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The Fusogen EFF-1 Controls Sculpting of Mechanosensory Dendrites
Making Menorahs Highly branched neuronal processes are typical of numerous neurons. The mechanisms controlling the formation, maintenance and regeneration of neuronal trees are poorly understood.Expand
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