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Biomedical engineering strategies for peripheral nerve repair: surgical applications, state of the art, and future challenges.
Damage to the peripheral nervous system is surprisingly common and occurs primarily from trauma or a complication of surgery. Although recovery of nerve function occurs in many mild injuries,Expand
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Extreme Stretch Growth of Integrated Axons
Large animals can undergo enormous growth during development, suggesting that axons in nerves and white matter tracts rapidly expand as well. Because integrated axons have no growth cones to extendExpand
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An In Vitro Uniaxial Stretch Model for Axonal Injury
AbstractWe have developed a unique uniaxial stretching device to study axonal injury and neural cell death resulting from brain tissue deformations common in traumatic head injuries. UsingExpand
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Injury-induced alterations in CNS electrophysiology.
Mild to moderate cases of traumatic brain injury (TBI) are very common, but are not always associated with the overt pathophysiogical changes seen following severe trauma. While neuronal death hasExpand
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Development of transplantable nervous tissue constructs comprised of stretch-grown axons
Pursuing a new approach to nervous system repair, fasciculated axon tracts grown in vitro were developed into nervous tissue constructs designed to span peripheral nerve or spinal cord lesions. WeExpand
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Role of Matrix Metalloproteinases in the Pathogenesis of Traumatic Brain Injury
Traumatic brain injury (TBI) is a major cause of mortality and morbidity worldwide. Studies revealed that the pathogenesis of TBI involves upregulation of MMPs. MMPs form a large family of closelyExpand
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NEURAL ENGINEERING TO PRODUCE IN VITRONERVE CONSTRUCTS AND NEUROINTERFACE
OBJECTIVERecently, our laboratory recapitulated a natural form of axon growth that occurs between late embryogenesis and early adulthood. In this article, we describe how this novel neuralExpand
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Traumatic brain injury induced matrix metalloproteinase2 cleaves CXCL12α (stromal cell derived factor 1α) and causes neurodegeneration
Traumatic brain injury (TBI), even at mild levels, can activate matrix metalloproteinases (MMPs) and the induction of neuroinflammation that can result in blood brain barrier breakdown andExpand
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Head Motions While Riding Roller Coasters: Implications for Brain Injury
The risk of traumatic brain injury (TBI) while riding roller coasters has received substantial attention. Case reports of TBI around the time of riding roller coasters have led many medicalExpand
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Engineering a high throughput axon injury system
Several key biological mechanisms of traumatic injury to axons are being elucidated using in vitro stretch injury models. However, these models are based on the experimentation of single culturesExpand
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