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The α(1,3)Fucosyltransferase Fuc-TVII Controls Leukocyte Trafficking through an Essential Role in L-, E-, and P-selectin Ligand Biosynthesis
TLDR
It is demonstrated here that mice deficient in alpha(1,3) fucosyltransferase Fuc-TVII exhibit a leukocyte adhesion deficiency characterized by absent leukocytes E- and P-selectin ligand activity and deficient HEV L- selectin ligands activity. Expand
Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense.
TLDR
Rac2-deficient mice were created to define the physiological requirement for two near-identical Rac proteins in hematopoietic cells, and showed significant defects in chemotaxis, in shear-dependent L-selectin-mediated capture on the endothelial substrate Glycam-1, and in both F-actin generation and p38 and p42/p44 MAP kinase activation induced by chemoattractants. Expand
Core 2 oligosaccharide biosynthesis distinguishes between selectin ligands essential for leukocyte homing and inflammation.
TLDR
It is indicated that core 2 oligosaccharide biosynthesis segregates the physiologic roles of selectins and reveal a function for the C2 GlcNAcT in myeloid homeostasis and inflammation. Expand
Dominant negative mutation of the hematopoietic-specific Rho GTPase, Rac2, is associated with a human phagocyte immunodeficiency.
TLDR
The syndrome of Rac2 dysfunction represents a human condition associated with mutation of a Rho GTPase and is another example of human disease associated with abnormalities of small G protein signaling pathways. Expand
The NFAT-1 DNA binding complex in activated T cells contains Fra-1 and JunB.
TLDR
Results suggested that the JunB-Fra-1 heterodimer is the inducible nuclear component of the NFAT-1 binding activity and that JunB expression regulates the formation of the heterodimers. Expand
An inducible cytoplasmic factor (AU-B) binds selectively to AUUUA multimers in the 3' untranslated region of lymphokine mRNA.
TLDR
A sequence-specific cytoplasmic factor (AU-B) that binds specifically to AUUUA multimers present in the 3' untranslated region of lymphokine mRNAs is reported, suggesting that AU-B is a cytopLasmic regulator ofymphokine mRNA metabolism. Expand
cis-acting sequences required for inducible interleukin-2 enhancer function bind a novel Ets-related protein, Elf-1.
TLDR
Two potential Ets binding sites, EBS1 and EBS2, which are conserved in both the human and murine interleukin-2 enhancers are identified, demonstrating that multiple Ets family members with apparently distinct DNA binding specificities regulate differential gene expression in resting and activated T cells. Expand
The alpha(1,3)fucosyltransferases FucT-IV and FucT-VII exert collaborative control over selectin-dependent leukocyte recruitment and lymphocyte homing.
TLDR
It is shown here that inflammation-dependent leukocyte recruitment retained in FucT-VII deficiency is extinguished in FucaT-IV(-/-)/FucT -VII(-/-) mice, and essential Fuct-IV-dependent contributions to E-, P-, and L-selectin ligand synthesis and to the control of leukocytes recruitment and lymphocyte homing are revealed. Expand
Novel Sulfated Lymphocyte Homing Receptors and Their Control by a Core1 Extension β1,3-N-Acetylglucosaminyltransferase
TLDR
Core1-beta 3GlcNAcT and its cognate extended core1 O-glycans are identified as essential participants in the expression of the MECA-79-positive, HEV-specific L-selectin ligands required for lymphocyte homing. Expand
Characterization of CTLA-4 structure and expression on human T cells.
TLDR
It is shown that within the T cell population, CTLA-4 expression is restricted to the subset of T cells that also express cell surface CD28, and the results suggest that B7 can bind to T cells via distinct receptor complexes consisting of either CD28 or CTLA, and that these complexes may potentially mediate distinct biologic functions. Expand
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