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Mesenchymal Stem Cells: Mechanisms of Immunomodulation and Homing
Mesenchymal stem cell (MSC) transplantation has been explored as a new clinical approach to repair injured tissue. A growing corpus of studies have highlighted two important aspects of MSC therapy:Expand
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Mesenchymal Stem Cell-Derived Molecules Reverse Fulminant Hepatic Failure
Modulation of the immune system may be a viable alternative in the treatment of fulminant hepatic failure (FHF) and can potentially eliminate the need for donor hepatocytes for cellular therapies.Expand
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Mesenchymal stem cells as therapeutics.
Mesenchymal stem cells (MSCs) are multipotent cells that are being clinically explored as a new therapeutic for treating a variety of immune-mediated diseases. First heralded as a regenerativeExpand
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Mesenchymal stem cell–derived molecules directly modulate hepatocellular death and regeneration in vitro and in vivo
Orthotopic liver transplantation is the only proven effective treatment for fulminant hepatic failure (FHF), but its use is limited because of organ donor shortage, associated high costs, and theExpand
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Immunomodulation of activated hepatic stellate cells by mesenchymal stem cells.
Bone marrow-derived mesenchymal stem cells (MSCs) have been reported to prevent the development of liver fibrosis in a number of pre-clinical studies. Marked changes in liver histopathology andExpand
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Long-term superior performance of a stem cell/hepatocyte device for the treatment of acute liver failure.
Cell-based technologies to support/restore organ function represent one of the most promising avenues in the treatment of acute liver failure (ALF). Recently, mesenchymal stem cells (MSCs) have beenExpand
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Reactive bone marrow stromal cells attenuate systemic inflammation via sTNFR1.
Excessive systemic inflammation following trauma, sepsis, or burn could lead to distant organ damage. The transplantation of bone marrow stromal cells or mesenchymal stem cells (MSCs) has beenExpand
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Gap junction inhibition prevents drug-induced liver toxicity and fulminant hepatic failure
Drug-induced liver injury (DILI) limits the development and application of many therapeutic compounds and presents major challenges to the pharmaceutical industry and clinical medicine.Expand
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Implantable microenvironments to attract hematopoietic stem/cancer cells
  • J. Lee, M. Li, +14 authors B. Parekkadan
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 12 November 2012
The environments that harbor hematopoietic stem and progenitor cells are critical to explore for a better understanding of hematopoiesis during health and disease. These compartments often areExpand
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Cell–cell interaction modulates neuroectodermal specification of embryonic stem cells
The controlled differentiation of embryonic stem (ES) cells is of utmost interest to their clinical, biotechnological, and basic science use. Many investigators have combinatorially assessed the roleExpand
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