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Some new, simple and efficient stereological methods and their use in pathological research and diagnosis
Stereology is a set of simple and efficient methods for quantitation of three‐dimensional microscopic structures which is specifically tuned to provide reliable data from sections. Within the lastExpand
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The new stereological tools: Disector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis
The new stereological methods for correct and efficient sampling and sizing of cells and other particles are reviewed. There is a hierarchy of methods starting from the simplest where even theExpand
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Neocortical neuron number in humans: Effect of sex and age
Modern stereological methods provide precise and reliable estimates of the number of neurons in specific regions of the brain. We decided to estimate the total number of neocortical neurons in theExpand
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Marked loss of myelinated nerve fibers in the human brain with age
The white matter is the structure of the brain that declines most with age—almost 30%, but little is known about the age‐effect on the fibers that constitute the white matter. In the present study,Expand
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Neocortical glial cell numbers in human brains
Stereological cell counting was applied to post-mortem neocortices of human brains from 31 normal individuals, age 18-93 years, 18 females (average age 65 years, range 18-93) and 13 males (averageExpand
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Age-Induced White Matter Changes in the Human Brain: A Stereological Investigation
In the present pilot study, age-related white matter changes were investigated by the use of design-based stereological methods. In the brains of elderly subjects, the total volume of the whiteExpand
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Aging and the human neocortex
Neurostereology has been applied to quantitative anatomical study of the human brain. Such studies have included the total neocortical number of neurons and glial cells, the estimated sizeExpand
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Aging of the human cerebellum: A stereological study
Cerebella from 19 normal Caucasian males, ages 19–84 years, were studied using stereological methods. Cerebellum was divided into four different regions: the anterior and posterior lobe, the vermis,Expand
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A quantitative study of the human cerebellum with unbiased stereological techniques
Estimates of total number of different neuron and glial cell types in the dentate nuclei and the four major regions of the human cerebellum were obtained by new stereological methods. With theExpand
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Pronounced reduction of total neuron number in mediodorsal thalamic nucleus and nucleus accumbens in schizophrenics.
  • B. Pakkenberg
  • Psychology, Medicine
  • Archives of general psychiatry
  • 1 November 1990
Using a new and unbiased stereological technique, the total numbers of neuron and glial cells in the mediodorsal thalamic nucleus and the nucleus accumbens were found to be significantly reduced inExpand
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