• Publications
  • Influence
Genetic Deficit of SK3 and IK1 Channels Disrupts the Endothelium-Derived Hyperpolarizing Factor Vasodilator Pathway and Causes Hypertension
Background— It has been proposed that activation of endothelial SK3 (KCa2.3) and IK1 (KCa3.1) K+ channels plays a role in the arteriolar dilation attributed to an endothelium-derived hyperpolarizingExpand
  • 204
  • 14
Endothelial Ca2+‐activated K+ channels in normal and impaired EDHF–dilator responses – relevance to cardiovascular pathologies and drug discovery
The arterial endothelium critically contributes to blood pressure control by releasing vasodilating autacoids such as nitric oxide, prostacyclin and a third factor or pathway termedExpand
  • 166
  • 11
Renal fibrosis is attenuated by targeted disruption of KCa3.1 potassium channels
Proliferation of interstitial fibroblasts is a hallmark of progressive renal fibrosis commonly resulting in chronic kidney failure. The intermediate-conductance Ca2+-activated K+ channel (KCa3.1) hasExpand
  • 136
  • 6
Vascular KCa-channels as therapeutic targets in hypertension and restenosis disease
Importance of the field: Cardiovascular disease is a leading cause of death in modern societies. Hyperpolarizing Ca2+-activated K+ channels (KCa) are important membrane proteins in the control ofExpand
  • 90
  • 4
Key role of dual specificity kinase TTK in proliferation and survival of pancreatic cancer cells
Background:Pancreatic ductal adenocarcinoma (PDAC) is among the most aggressive human malignancies with an overall 5-year survival rate of <5%. Despite significant advances in treatment of theExpand
  • 39
  • 1
Systematic comparison of RNA extraction techniques from frozen and fresh lung tissues: checkpoint towards gene expression studies
BackgroundThe reliability of gene expression profiling-based technologies to detect transcriptional differences representative of the original samples is affected by the quality of the extracted RNA.Expand
  • 37
The deubiquitinating enzyme USP5 promotes pancreatic cancer via modulating cell cycle regulators
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal solid tumors. With an overall five-year survival rate remaining below 6%, there is an explicit need to search for new molecularExpand
  • 12
  • PDF
Downregulation of miR-503 in Activated Kidney Fibroblasts Disinhibits KCNN4 in an in Vitro Model of Kidney Fibrosis
Background/Aims: Activated fibroblasts are key controllers of extracellular matrix turnover in kidney fibrosis, the pathophysiological end stage of chronic kidney disease. The proliferation ofExpand
  • 2
Localizes to the Inner PlasmaMembrane of PancreaticCancerCells andRegulatesCellGrowth and Disease Progression through Critical Cell-Cycle Regulatory Pathways
Pancreatic ductal adenocarcinoma (PDAC) carries the most dismal prognosis of all solid tumors and is generally strongly resistant to currently available chemoand/or radiotherapy regimens, includingExpand