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Microbial Regulation of Glucose Metabolism and Cell-Cycle Progression in Mammalian Colonocytes
A prodigious number of microbes inhabit the human body, especially in the lumen of the gastrointestinal (GI) tract, yet our knowledge of how they regulate metabolic pathways within our cells isExpand
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Defective postreplication repair in xeroderma pigmentosum variant fibroblasts.
Postreplication repair (PRR) was quantified in normal human fibroblasts and in xeroderma pigmentosum (XP) variant fibroblasts after treatment with UV or benzo[a]pyrene diol epoxide-I (BPDE-I). PRRExpand
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Differentiation between dynamic instability and end-to-end annealing models for length changes of steady-state microtubules.
Short microtubules can be formed by shearing a sample at polymerization steady state of microtubules formed by glycerol-induced assembly of pure tubulin dimer. Such short microtubules show a rapidExpand
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Mapping of an origin of DNA replication in the promoter of fragile X gene FMR1.
An origin of bidirectional DNA replication was mapped to the promoter of the FMR1 gene in human chromosome Xq27.3, which has been linked to the fragile X syndrome. This origin is adjacent to a CpGExpand
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Rate for nucleotide release from tubulin.
The lower limit for the first order rate constant for dissociation of GDP from the tubulin E-site has been determined to be 0.14 s-1; this corresponds to a reaction with a half-life of 5 s. UsingExpand
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Mapping of an origin of DNA replication near the transcriptional promoter of the human HPRT gene
A quantitative PCR method was used to map a functional origin of DNA replication in the hypoxanthine‐guanine phosphoribosyltransferase (HPRT) gene in normal human fibroblasts. This PCR methodExpand
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Same origins of DNA replication function on the active and inactive human X chromosomes
We previously characterized a functional origin of DNA replication at the transcriptional promoter of the human hypoxanthine‐guanine phosphoribosyltransferase (HPRT) gene (Cohen et al. [ 2002 ] J.Expand
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Complementation of replication origin function in mouse embryonic stem cells by human DNA sequences.
A functional origin of replication was mapped to the transcriptional promoter and exon 1 of the hypoxanthine-guanine phosphoribosyltransferase (HPRT) gene in the mouse and human genomes. This originExpand
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Concerning the anomalous kinetic behavior of microtubules.
We have demonstrated that tubulin-GTP subunits can react with microtubule ends containing subunits with E-site-bound GDP. This observation can be taken to rule out a previous interpretation of aExpand
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On the relationship of matrix association and DNA replication.
The nuclear matrix is believed to contain sites of assembly of protein complexes that catalyze the initiation of DNA replication as well as DNA elongation. To explore this relationship, DNAExpand
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