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Distinct functional and pharmacological properties of tonic and quantal inhibitory postsynaptic currents mediated by gamma-aminobutyric acid(A) receptors in hippocampal neurons.
- D. Bai, G. Zhu, P. Pennefather, M. Jackson, J. Macdonald, B. Orser
- Chemistry, Medicine
- Molecular pharmacology
- 1 April 2001
gamma-Aminobutyric acid (GABA), the principal inhibitory neurotransmitter, activates a persistent low amplitude tonic current in several brain regions in addition to conventional synaptic currents.… Expand
Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by α5 subunit-containing γ-aminobutyric acid type A receptors
The principal inhibitory neurotransmitter in the mammalian brain, γ-aminobutyric acid (GABA), is thought to regulate memory processes by activating transient inhibitory postsynaptic currents. Here we… Expand
Communication failures in the operating room: an observational classification of recurrent types and effects
Background: Ineffective team communication is frequently at the root of medical error. The objective of this study was to describe the characteristics of communication failures in the operating room… Expand
G-protein-coupled receptors act via protein kinase C and Src to regulate NMDA receptors
The N-methyl-D-aspartate (NMDA) receptor contributes to synaptic plasticity in the central nervous system and is both serine-threonine and tyrosine phosphorylated. In CA1 pyramidal neurons of the… Expand
Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by alpha5 subunit-containing gamma-aminobutyric acid type A receptors.
- Valerie B Caraiscos, Erin M. Elliott, +9 authors B. Orser
- Proceedings of the National Academy of Sciences…
The principal inhibitory neurotransmitter in the mammalian brain, gamma-aminobutyric acid (GABA), is thought to regulate memory processes by activating transient inhibitory postsynaptic currents.… Expand
Suppression of hippocampal TRPM7 protein prevents delayed neuronal death in brain ischemia
Cardiac arrest victims may experience transient brain hypoperfusion leading to delayed death of hippocampal CA1 neurons and cognitive impairment. We prevented this in adult rats by inhibiting the… Expand
Emerging molecular mechanisms of general anesthetic action.
- H. Hemmings, M. Akabas, P. A. Goldstein, J. Trudell, B. Orser, N. Harrison
- Chemistry, Medicine
- Trends in pharmacological sciences
- 1 October 2005
General anesthetics are essential to modern medicine, and yet a detailed understanding of their mechanisms of action is lacking. General anesthetics were once believed to be "drugs without receptors"… Expand
Metaplasticity gated through differential regulation of GluN2A versus GluN2B receptors by Src family kinases
- K. Yang, Catherine Trepanier, +9 authors J. Macdonald
- Biology, Medicine
- The EMBO journal
- 15 February 2012
Metaplasticity is a higher form of synaptic plasticity that is essential for learning and memory, but its molecular mechanisms remain poorly understood. Here, we report that metaplasticity of… Expand
Design and screening of ASIC inhibitors based on aromatic diamidines for combating neurological disorders.
Acid sensing ion channels (ASICs) are implicated in various brain functions including learning and memory and are involved in a number of neurological disorders such as pain, ischemic stroke,… Expand
Evaluation of a preoperative checklist and team briefing among surgeons, nurses, and anesthesiologists to reduce failures in communication.
OBJECTIVE To assess whether structured team briefings improve operating room communication. DESIGN, SETTING, AND PARTICIPANTS This 13-month prospective study used a preintervention/postintervention… Expand