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Stress revisited: A critical evaluation of the stress concept
TLDR
It is proposed that the term 'stress' should be restricted to conditions where an environmental demand exceeds the natural regulatory capacity of an organism, in particular situations that include unpredictability and uncontrollability.
A new animal welfare concept based on allostasis
TLDR
This paper is aimed at a broader scientific discussion of animal welfare that includes knowledge from the latest scientific developments in neurobiology and behavioral physiology, and generates views that are extremely relevant for the animal welfare discussion.
The stress-induced hyperthermia paradigm as a physiological animal model for anxiety: A review of pharmacological and genetic studies in the mouse
TLDR
The function, brain mechanisms and pharmacology of stress-induced hyperthermia (SIH) in a broad context, and some of the limitations of the SIH procedure for use of drugs like nicotine, which contain particular characteristics such as short in vivo half-life, and/or disturbance of thermoregulation are presented.
Transcriptional and behavioral interaction between 22q11.2 orthologs modulates schizophrenia-related phenotypes in mice
TLDR
Transcriptional profiling and pharmacological manipulations identified a transcriptional and behavioral interaction between the Prodh and Comt genes that is likely to represent a homeostatic response to enhanced dopaminergic signaling in the frontal cortex.
Effect of SSRI antidepressants on ejaculation: a double-blind, randomized, placebo-controlled study with fluoxetine, fluvoxamine, paroxetine, and sertraline.
TLDR
In men with lifelong rapid ejaculation, paroxetine delayed ejaculation most strongly, whereas fluvoxamine delayed ejaculations the least, which suggests that ejaculation-delaying side effects of some SSRIs investigated in men with generalized rapid ejaculations may be extrapolated to men with less-rapid ejaculation.
The bovine protein alpha-lactalbumin increases the plasma ratio of tryptophan to the other large neutral amino acids, and in vulnerable subjects raises brain serotonin activity, reduces cortisol
TLDR
Testing whether alpha-lactalbumin, a whey protein with a high tryptophan content, may increase the plasma Trp-LNAA ratio and reduce depressive mood and cortisol concentrations in stress-vulnerable subjects under acute stress found it improved coping ability.
Social cognition in schizophrenia: recommendations from the measurement and treatment research to improve cognition in schizophrenia new approaches conference.
TLDR
One of the objectives of this group was to generate recommendations for subsequent human and animal studies, and these research agendas are summarized in this report.
Intranasal administration of oxytocin: Behavioral and clinical effects, a review
TLDR
It is concluded that IN-OT administration may be a promising approach to influence human communication but that the existing lack of information about the neural and physiological mechanisms involved is a serious problem for the proper understanding and interpretation of the observed effects.
Stress-induced hyperthermia and anxiety: pharmacological validation.
TLDR
The stress-induced hyperthermia test in singly housed male and female mice appears a useful and extremely simple test to measure effects of drugs on certain aspects of anxiety or to help to determine phenotypic differences in mutant mice.
Relevance of methodological design for the interpretation of efficacy of drug treatment of premature ejaculation: a systematic review and meta-analysis
TLDR
At daily treatment, the overall efficacy of paroxetine, clomipramine, sertraline and fluoxetines is comparable, but paroxettine exerts the strongest ejaculation delay.
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