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Phosphorylation of mammalian CDC6 by Cyclin A/CDK2 regulates its subcellular localization
Cyclin‐dependent kinases (CDKs) are essential for regulating key transitions in the cell cycle, including initiation of DNA replication, mitosis and prevention of re‐replication. Here we demonstrateExpand
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Cell cycle- and cell growth-regulated proteolysis of mammalian CDC6 is dependent on APC-CDH1.
CDC6 is conserved during evolution and is essential and limiting for the initiation of eukaryotic DNA replication. Human CDC6 activity is regulated by periodic transcription and CDK-regulatedExpand
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Induction of S-phase entry by E2F transcription factors depends on their nuclear localization.
The E2F transcription factors are essential for regulating the correct timing of activation of several genes whose products are implicated in cell proliferation and DNA replication. The E2Fs areExpand
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Deregulated expression of E2F family members induces S-phase entry and overcomes p16INK4A-mediated growth suppression.
The E2F family of transcription factors regulate genes, whose products are essential for progression through the mammalian cell cycle. The transcriptional activity of the E2Fs is inhibited throughExpand
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Evidence implying only unprimed RdRP activity during transitive gene silencing in plants
RNA silencing is a sequence-specific RNA degradation mechanism found in most eukaryotes, where small cleavage products (siRNAs) of double stranded RNA (dsRNA) mediate silencing of genes with sequenceExpand
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Cell Cycle-Regulated Expression of MammalianCDC6 Is Dependent on E2F
ABSTRACT The E2F transcription factors are essential regulators of cell growth in multicellular organisms, controlling the expression of a number of genes whose products are involved in DNAExpand
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Cell cycle – and cell growth – regulated proteolysis of mammalian CDC 6 is dependent on APC – CDH 1
CDC6 is conserved during evolution and is essential and limiting for the initiation of eukaryotic DNA replication. Human CDC6 activity is regulated by periodic transcription and CDK-regulatedExpand
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Differential cytotoxic pathways of topoisomerase I and II anticancer agents after overexpression of the E2F-1/DP-1 transcription factor complex.
The transcription factor complex E2F-1/DP-1 regulates the G1-to-S-phase transition and has been associated with sensitivity to the S-phase-specific anticancer agents camptothecin and etoposide, whichExpand
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Isolation and RNA silencing of homologues of the RNase L inhibitor in Nicotiana species
Abstract Based on the sequences of mammalian RNase L inhibitors (RLI), homologues were identified in Arabidopsis thaliana and Nicotiana plant species. RLI homologue (RLIh) cDNAs were cloned fromExpand
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