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Antifilarial activity in vitro of polycarpol and 3-O-acetyl aleuritolic acid from cameroonian medicinal plants against Onchocerca gutturosa
Three compounds are isolated and screened and only polycarpol and 3-O-acetyl aleuritolic acid exhibited significant inhibitory activities on the vitality of adult male worms of O. gutturosa using Amocarzine as positive control compound. Expand
Antibacterial activity of selected Cameroonian dietary spices ethno-medically used against strains of Mycobacterium tuberculosis.
The results of this study suggest that Echinops giganteus and Piper guineense could be important sources of bactericidal compounds against M. tuberculosis and could probably be promising candidates that can be further investigated. Expand
Mandassidione and other sesquiterpenic ketones from Cyperus articulatus
Abstract A new monocyclic sesquiterpenic diketone, mandassidione, was isolated from the rhizomes of Cyperus articulatus , along with mustakone and isopatchoul-4(5) en-3-one. The structures were… Expand
In vitro inhibitory effects of palmatine from Enantia chlorantha on Trypanosoma cruzi and Leishmania infantum
- E. Nkwengoua, I. Ngantchou, B. Nyassé, C. Denier, C. Blonski, B. Schneider
- Biology, Medicine
- Natural product research
- 15 August 2009
In an attempt to establish the components responsible for the use of Enantia chlorantha against cutaneous leishmaniasis in local traditional medicine, a well-known palmatine has been isolated in… Expand
Antitrypanosomal alkaloids from Polyalthia suaveolens (Annonaceae): their effects on three selected glycolytic enzymes of Trypanosoma brucei.
- I. Ngantchou, B. Nyassé, C. Denier, C. Blonski, V. Hannaert, B. Schneider
- Chemistry, Medicine
- Bioorganic & medicinal chemistry letters
- 15 June 2010
Stem barks of Polyalthia suaveolens were phytochemically studied and yielded a new indolosesquiterpene alkaloid, named polysin, and four hitherto known alkaloids, which exhibited interesting inhibitory effects on selected glycolytic enzymes. Expand
Gastric cytoprotective anti-ulcer effects of the leaf methanol extract of Ocimum suave (Lamiaceae) in rats.
The results suggest that a new anti-ulcer therapy regimen may be formulated which does not require the use of antacids and anti-secretory agents. Expand
7α,20(S)-Dihydroxy-4,24(28)-ergostadien-3-one from Entandrophragma utile
A new sterol, 7α,20(S)-dihydroxy-4,24(28)-ergostadien-3-one (1), has been isolated from the bark of Entandrophragma utile and its structure elucidated by 1H- and 13C-NMR spectroscopic methods.
Trypanocidal activity of bergenin, the major constituent of Flueggea virosa, on Trypanosoma brucei.
Bergenin showed an inhibitory effect on the growth of the bloodstream form of Trypanosoma brucei with an IC50 value of 1 microM. Expand
Aporphine alkaloids from Enantia chlorantha
Two novel aporphine alkaloids, named 6a,7-dehydro-1,2-dimethoxy-7-hydroxy- N -methylaporphine and 6a. Expand
Anti-ulcer actions of the bark methanol extract of Voacanga africana in different experimental ulcer models in rats.
The bark methanol extract significantly reduced gastric lesion formation in pylorus ligated rats, but this was not associated with an increase in gastric mucus production or with a reduction in acid content, volume of gastric secretion or pepsin activity of the gastric juice. Expand